摘要
目的 针对血清胆红素的强抗氧化性质 ,研究其与动脉粥样硬化 (AS)的关系。 方法 采用重氮法测定血清胆红素 ,酶法测定总胆固醇 (TC)、甘油三酯 (TG) ,选择性抑制法测定高密度脂蛋白胆固醇 (HDLC) ,低密度脂蛋白胆固醇 (L DLC) ,通过 Friedward公式计算。 结果 冠心病患者的总胆红素、直接胆红素及间接胆红素均低于对照组 (P<0 .0 5 ) ,脑梗塞患者的总胆红素、间接胆红素低于对照组 (P<0 .0 5 ) ,其他疾病组这 3项指标与对照组比较差异无显著性 (P>0 .0 5 )。 结论 血清胆红素浓度低下引起体内抗氧化活性不同程度减弱 ,可能会促使脂质尤其是低密度脂蛋白 (L DL )氧化修饰增多 ,导致动脉粥样硬化的发生和发展。
Objective\ To study the association of serum concentration of bilirubin and its strong antioxidation with atherosclerosis.\ Methods\ Serum bilirubin was determined with Malloy-Evelyn.\ Total cholesterol(TC),triglycerides(TG) were determined with enzymology,high density lipoproteins(HDL\-C) was determined with elimination enzymatic assay,low density lipoprotein(LDL\-C) was calculated with Friedward formula.\ Results\ The concentration of total bilirubin and indirect bilirubin in coronary heart disease were lower than those in the controls(P<0 05).\ The concentration of bilirubin in other diseases were the same as in the controls(P>0 05).\ Conclusion\ Lower serum bilirubin concentration possibly reduces the antioxidant activities.\ It is possible to expedite lipid and low density lipoprotein peroxidation,lower serum bilirubin is associated with increased risk for atherosclerosis.\;
出处
《福建医科大学学报》
2000年第3期259-260,265,共3页
Journal of Fujian Medical University
基金
福建省卫生厅青年科研基金!资助项目 (99-0 1-19)
