摘要
目的比较分析肺源性与不同程度心源性呼吸困难患者血清癌抗原125(CA125)、B型钠尿肽(BNP)水平及其临床价值。方法对以呼吸困难为主诉的192例患者按病因分成心源性和肺源性两组,心源性组又分成Ⅱ级、Ⅲ级、Ⅳ级三个亚组,分别测定其入院时及心功能不全控制后的血清CAl25和BNP水平,分析心源性和肺源性两组间入院时CAl25和BNP水平的差异,不同程度心功能不全组间CAl25、BNP水平的差异及其两者间的相关性。结果心源性呼吸困难组的CA125与BNP水平显著高于肺源性呼吸困难组(P<0.01);在心源性呼吸困难组中,随着心功能分级的升高,CAl25、BNP水平也分别显著升高(P<0.01);而且不同程度心功能不全组的CAl25与BNP水平间存在显著正相关(r=0.86,P<0.05)。结论 CA125可以与BNP一样作为心源性呼吸困难的诊断指标,且两者还可以作为心功能不全程度的判断依据。
Objective To compare and analyze the serum cancer antigen 125 （CA125） and B-type natriuretic peptide （BNP） level as well as the clinical values of breathing difficulties patients for pulmonary and different degrees of cardiogenic. Method Based on the types of cause, 192 patients suffering breathing difficulty were divided into two groups： a cardiogenic group and a pulmonary group. The cardiogenic group was divided into three subgroups： Grade Ⅱ , Grade Ⅲ , Grade Ⅳ. The readings of CA125 level and BNP level were taken at admission and after the heart dysfunction control. The differences of the CA125 level and the BNP level in both groups obtained at admission were analyzed. The differences of the CA125 level and the BNP level of the patients with different degrees of ventricular dysfunction and the correlations therein were also analyzed. Results The CA125 level and the BNP level of the cardiogenic group were significantly higher than those of the pulmonary group（P 〈 0.01 ）. In the cardiogenic group, with elevated heart function grade, the CA125 level and the BNP level were also significantly improved （P 〈 0. 01 ）. It could also be observed that there was significant positive correlation between the CA125 level and the BNP level in the ventricular dysfunction group （ r = 0.86, P 〈 0.05）. Conclusion The CA125 can be a diagnositic indicator as well as the BNP level. Both can serve as indicators for determining the degrees of ventricular dysfunction.
出处
《健康研究》
CAS
2013年第1期46-48,共3页
Health Research
