摘要
目的:观察肝肾阳虚型抑郁症与血清甲状腺激素关系及助阳舒心方的干预作用。方法:将100例肝肾阳虚型抑郁症患者随机分为治疗组和对照组,其中治疗组用助阳舒心方治疗,对照组用氟西汀治疗,疗程均为6周,比较血清甲状腺激素在治疗前后的变化,分析治疗前HAMD总分、中医证候积分与血清甲状腺激素的相关性,分析治疗前后HAMD总分、中医证候积分减分率与血清甲状腺激素减分率的相关性。结果:肝肾阳虚型抑郁症治疗前TSH高于正常者占17.71%、T3低于正常者占30.21%、T4低于正常者占18.75%;治疗前HAMD总分与TSH含量具有正相关的关系,与T3、T4含量具有负相关的关系;治疗前证候积分与T4含量具有负相关的关系;治疗前后HAMD总分减分率与TSH减分率具有正相关的关系;两组治疗前后TSH、T3、T4的组内比较具有显著的统计学意义(P<0.01)。结论:肝肾阳虚型抑郁症与甲状腺激素变化有关,TSH升高、T3和T4的降低与病情严重程度有关,T4的降低可用于证候诊断的参考,TSH减分率可用于临床疗效评估的参考,调控内分泌功能可能是助阳舒心方治疗抑郁症的机制之一。
Objective：To observe the relationship between depression of liver-kidney yang deficiency type and serum thyroid hormone and intervention of Zhuyang Shuxin prescription.Methods：100 cases were randomly divided into treatment group which was treated with Zhuyang Shuxin prescription and control group which was treated with fluoxetine for six weeks.Serum thyroid hormone was observed before and after treatment.The correlation between HAMD total score,TCM syndrome score and serum thyroid hormone before treatment were explored,the correlation between HAMD total score,TCM syndrome score reducing rate and serum thyroid hormone score reducing rate before and after treatment were explored.Results：TSH was higher than that of normal person in depression of liver-kidney yang deficiency type,accountting for 17.71%;T3 was lower than that of normal person,accountting for 30.21%;T4 was lower than that of normal person,accountting for 18.75% before treatment.HAMD total score had a positive correlation with TSH and had a negative correlation with T3 and T4 before treatment.Syndrome scoring had a negative correlation with T4 before treatment.HAMD score reducing rate had a positive correlation with TSH score reducing rate before and after treatment.There were significant statistical differences in T3,T4 and TSH in both group before and after treatment（P〈0.01）.Conclusion：Depression of liver-kidney yang deficiency type is related to serum thyroid hormone.The increased TSH,decreased T3 and T4 are related to the severity of depression.The decreased T4 could be a reference for syndrome diagnosis,TSH score reducing could be a reference for valuation of clinical effect.The regulation effect on endocrine function may be one of the mechanism of Zhuyang Shuxin prescription in treating depression.
出处
《中华中医药学刊》
CAS
2013年第3期554-556,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药优秀青年人才基金资助项目(2010ZQ016)
台州恩泽医疗中心(集团)科研基金资助项目(11EZD21)
