摘要
目的碳酸氢钠水化疗法对比氯化钠水化疗法的有效性。方法检索Medline,Pubmed,and the Internet、万方、维普数据库中自2008年以来的关于碳酸氢钠水化及氯化钠水化疗法的完全随机对照试验。使用统计软件RevMan5.0完成Meta分析。结果经过筛选,最后入选的文章有7篇,均是以氯化钠为对照的完全随机对照试验。包括受试患者1817人。进行meta分析,其基线情况具有可比性。通过比较不同水化疗法后造影剂肾病的发生率,发现碳酸氢钠水化疗法对比氯化钠水化疗法相比无统计学差异。结论碳酸氢钠水化疗法相比氯化钠水化疗法对预防造影剂肾病,可以减少造影剂肾病的发生率,但是两组间无统计学差异,对于需要透析的病人两组间无明显差异。
Objective To compare the effectiveness of hydration therapy with sodium bicarbonate with that of hydration therapy with sodium chloride. Methods A search was performed using Medline, PubMed, Interact, Wanfang Data, and CQVIP to find the randomized controlled trials on hydration therapy with sodium bicarbonate and hydration therapy with sodium chloride published since 2008. A recta-analysis was performed using statistical software RevMan 5.0. Results Seven papers, all of which were about randomized controlled trials with sodium chloride as a control, were included in the analysis. A total of 1817 subjects were enrolled in the trials. There was comparability at baseline in the recta-analysis. There was no statistically significant difference in the incidence of radiographic contrast nephropathy between the subjects who had received hydration therapy with sodium bicarbonate and hydration therapy with sodium chloride. Conclusion Compared with hydration therapy with sodium chloride, hydration therapy with sodium bicarbonate can reduce the incidence of radiographic contrast nephropathy, but there is no statistically significant difference between them. No significant difference is found between the two therapies for the patients in need of dialysis.
出处
《心血管病防治知识（学术版）》
2013年第2期75-78,共4页
Prevention and Treatment of Cardiovascular Disease
关键词
碳酸氢钠
水化疗法
造影剂肾病
Sodium bicarbonate
Hydration therapy
Radiographic contrast nephropathy
