摘要
目的:分析丹参酮-ⅡA联合钾钴胺治疗糖尿病周围神经病变的临床疗效。方法:临床选取已确诊的糖尿病住院患者82例,按随机数字表法分为2组,对照组患者给予肌内注射甲钴胺(500μg),qd。治疗组于此基础上,加用丹参酮-ⅡA针剂50 mg静脉滴注,qd,4周为一个疗程,观察患者体内各项指标的变化并分析。结果:治疗组总有效率92.68%;对照组总有效率53.66%,2组比较,差异有统计学意义(P<0.05)。治疗组患者治疗前后血液黏度、纤维蛋白原和红细胞聚集指数都有降低,且差异有统计学意义(P<0.05)。治疗组患者治疗后血液黏度、纤维蛋白原和红细胞聚集指数均较对照组低,2组比较,差异有统计学意义(P<0.05)。治疗组治疗前后腓总神经、正中神经、腓肠神经的神经传导速度有显著提高,差异有统计学意义(P<0.05)。治疗组治疗后腓肠神经的神经传导速度较对照组提高,且差异有统计学意义(P<0.05)。结论:丹参酮-ⅡA与甲钴胺联合治疗糖尿病周围神经病变能明显改善患者血液黏稠度,微循环和神经传导速度等指标,是治疗糖尿病周围神经病变的较好方法,值得临床推广。
ABSTRACT： OBJECTIVE To analyze the effect of tanshinoneⅡ A combined with potassium cobalt amine in treating diabetic peripheral neuropathy. METHODS 82 patients with diabetic peripheral neuropathy were randomly divided into two groups, control group and experimental group, the patients in the control group received the treatment of intramuscular injection of mecobalamin （500μg）, once a day. The patients in the experimental group were treated with tanshinone ⅡA injection, which was based on the control group, once a day. 4 week for a course of treatment. RESULTS In the experimental group, the total efficiency was 92.68~ ; while it was 53.66~ in the control group, the difference was significant （P^0. 05）. The blood vis- cosity, fibrinogen and erythrocyte aggregation index were reduced after the combination treatment in the experimental group, the differences were significant （P〈0. 05）. The above indexes of experimental group were also lowered than that in control group, the differences were also significant （P〈0. 05）. CONCLUSION The combination therapy can significantly improve the indexes including blood viscosity, microcirculation and nerve conduction velocity. It is a good method in the treatment of diabet- ic peripheral neuropathy, worthy of clinical application.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2013年第5期395-396,406,共3页
Chinese Journal of Hospital Pharmacy
关键词
丹参酮-ⅡA
钾钴胺
糖尿病周围神经病变
疗效
tanshinoneⅡ A
potassium cobalt amine
diabetic peripheral neuropathy
curative ef{ect
