摘要
目的 :研究血管紧张素转换酶 (ACE)基因多态性与冠心病的关系。方法 :应用聚合酶链式反应 (PCR)检测ACE基因第 16内含子I/D多态性 ,并计算基因型和等位基因频率。结果 :在 5 1例冠心病组中ACE基因DD基因型和D等位基因频率分别是 35 %和 6 1% ,83例正常对照组中的ACE基因DD基因型和D等位基因频率分别是 16 %和 45 % ,两者相比具有显著性差异。结论 :ACE基因DD基因型可能是冠心病发生发展过程中重要的危险因素之一。
Objective: To study the relationship between angiotensin converting enzyme (ACE) gene polymorphism and coronary heart disease (CHD). Methods: The polymerase chain reaction (PCR) was used to detect an insertion/deletion (I/D) polymorphism of ACE gene in its sixteen intron, then genotype and allele frequencies were calculated. Results: The DD genotype and D allele frequencies of ACE gene were 35% and 61% in 51 case with CHD and were 16% and 45% in 83 healthy subjects, respectively. The frequencies of DD genotype and D allele between two groups showed significant differences. Conclusions: the deletion polymorphism of ACE gene might be an important risk factor in the development of CHD.
出处
《中国现代医学杂志》
CAS
CSCD
2000年第6期13-13,15,共2页
China Journal of Modern Medicine
关键词
血管紧张素转换酶
基因多态性
冠心病
Angiotensin Converting Enzyme
Polymorphism Coronary Heart Disease
