摘要
目的 :观察大剂量环磷酰胺冲击治疗原发性难治性肾病综合征的疗效。方法 :对36例难治性肾病综合征患者给予环磷酰胺1g加入生理盐水500ml中静脉滴注 ,1mo1次 ,使用6次后改为3mo1次 ,累计总量达150mg·kg 1,并按完全缓解 ,部分缓解评定有效率。结果 :36例中完全缓解22例 ,部分缓解8例 ,有效率83 3 %。结论 :该疗法确有消除或减少尿蛋白 ,明显提高血浆白蛋白的作用 ,疗效好 。
Objective:To observe the therapeutic effect of large dosage of cyclophosphamide in the treatment of intractable nephrotic syndrome.Methods:One gram of cyclophosphamide in 500 ml 0.9% of normal saline was administered through vein in 36 cases with intractable nephrotic syndrome.The beginning administration was once a month for six months and then changed into one time every three months.The accumulated dosage amounted to 150 mg·Kg-1.The effective rate was finally evaluated according to the improvement of clinical manifestations.Results:Of the 36 cases,the manifestations were completely alleviated in 22 cases while partly alleviated in 8 cases.The total effective rate was 83.3%,Cibckysuibs:Cyclophosphamide has the effect of eliminating or reducing urine-protein and increasing serum-protein.Its therapeutic effect is good with a slight side effect.
出处
《大理医学院学报》
2000年第2期29-30,共2页
Journal of Dali Medical College
关键词
环磷酰胺
静脉冲击
肾病综合征
治疗
Cyclophosphamide
Stosstherapy through vein
Nephrotic syndrome
