摘要
目的:分析研究表皮生长因子(EGFR)在中国结直肠癌患者癌组织中的表达与淋巴结转移及肝脏转移的相关性。方法:利用万方、维普、CNKI、PubMed、Web of Science和EMBASE数据库,以"结直肠癌、结直肠肿瘤、大肠癌、EG-FR、表皮生长因子受体"为关键词,检索2000-2012年公开发表的关于结直肠癌患者癌组织中EGFR的表达与淋巴结转移及肝脏转移关系的文献,对文献进行筛选和评价,符合标准的文献用Revman 5.0软件进行Meta分析。结果:EG-FR表达与淋巴结转移相关文献入选17篇,共2 092例患者,淋巴结转移患者1 040例,523例EGFR阳性,无淋巴结转移者1 052例,327例EGFR阳性,异质性检验提示各研究结果间存在异质性(χ2=43.48,P=0.000 2,I2=63%),采用随机效应模型进行合并OR=3.17,95%CI=2.19～4.60,合并效应量的检验结果显示z=6.08,差异有统计学意义(P<0.01),提示有淋巴结转移的患者,癌组织中EGFR的表达高于无淋巴结转移者;EGFR表达与肝转移相关文献入选4篇,共385例患者,其中肝转移患者154例,90例EGFR阳性,无肝转移者231例,65例EGFR阳性,异质性检验存在异质性(χ2=14.44,P=0.002,I2=79%),采用随机效应模型进行合并,OR=3.99,95%CI=1.04～15.36,合并效应量的检验结果显示z=2.01,差异有统计学意义(P=0.04),提示有肝转移的患者,癌组织中EGFR的表达显著高于无肝转移者。结论:在中国结直肠癌患者中,发生淋巴结转移和肝转移的患者癌组织中EGFR的表达明显升高,EGFR检测对筛选高危转移者具有重要意义。
OBJECTIVE：To investigate the correlation of the expression of epidermal growth factor receptor（EGFR） and lymph node metastasis,liver metastasis in Chinese col0rectal cancer patients. METHODS： Systematic computerized searches of PubMed, web of science, EMBASE,Wanfang,eqvip and CNKI databases meeting specified search criteria were performed from year 2000 to 2012, withcolorectal carcinoma, colorectal cancer, EGFR, epidermal growth factor receptor as key words, followed by a further screening according to inclusive and exclusive criteria, and the data meeting the select- ed standard were collected,then meta-analysis was carried out by Revman 5.0. RESULTS： Seventeen reports about the correlation of EGFR expression and lymph node metastasis were selected based on the standard,including 2 092 patients, there were 1 040 patients with lymph node metastasis,and 523 cases were positive to EGFR 327 cases were positive to EGFR among 1 052 patients without lymph node metastasis, heterogeneity existed among these researches （X2 = 43.48, P=0. 000 2,I2 =63%） ,so Random effects model to merge was used （OR=3.17,95MCI=2.19=4.60）. The combined effect of the test results was Z= 6.08, the difference was statistically significant （P〈0.01）. The result indicated that EG- FR express higher in cancer tissues with lymph node metastasis. Four reports about the correlation of EGFR expression and liver metastasis were selected based on the standard,including 385 patients. There were 154 patients with liver metas- tasis,and 90 cases were positive to EGFRSixty-five cases were positive to EGFR among 231 patients without liver metas- tasis,and heterogeneity existed among these researches = 14.44, P = 0. 002, I2 = 79 %）, so Random effects model tomerge was used （OR--3.99,95%CI： 1. 04-15. 36） , the combined effect of the test results indicated z--2.01,and the difference was statistically significant （P= 0.04）. The result indicated that EGFR express higher in cancer tissues with liver metastasis. CONCLUSIONS：In
出处
《中华肿瘤防治杂志》
CAS
北大核心
2013年第4期304-308,共5页
Chinese Journal of Cancer Prevention and Treatment
基金
教育部留学回国人员科研启动基金(20111139)
吉林省科技发展计划(20080739
200905169)
关键词
结直肠肿瘤
受体
表皮生长因子
淋巴结转移
肝转移
META分析
colorectal neoplasms
receptor, epidermal growth factor
lymph node metastasis
liver metastasis
Meta-analysis
