摘要
目的 :观察自发性高血压大鼠胸主动脉结构的改变 ,以及依那普利和洛沙坦的保护作用。方法 :雄性自发性高血压大鼠自 10周龄始 ,给予依那普利、洛沙坦 ,或二者半剂量合用 6周 ,并以年龄、性别、数量相同的未治疗自发性高血压大鼠和正常对照组作对照。测量收缩压和血管壁胶原含量 ,计算机图像分析血管外膜面积、中膜面积、管腔面积和管壁厚度。结果 :自发性高血压大鼠未治疗组的收缩压、血管壁胶原含量、外膜面积、中膜面积和管壁厚度均显著高于正常对照组 (P <0 .0 0 1) ,自发性高血压大鼠各治疗组上述指标显著低于其对照组 ,血管腔面积在各组之间无显著性差别 (P >0 .0 5 )。结论 :自发性高血压大鼠早期大动脉结构的改变主要是血管壁结构的改变 ,依那普利和洛沙坦可有效地降低血压、改善血管重塑。
Objective: To investigate the structural changes of aorta in spontaneously hypertensive rats (SHR), and the protective role of enalapril and losartan. Methods: We administed angiotensin converting enzyme (ACE) inhibitor (enalapril 20mg.kg-1.d-1), AngII receptor type 1 (AT1) antagonist (losartan 25mg.kg-1.d-1), or their combination at half doses (enalapril 10mg.kg-1.d-1, losartan 12.5mg.kg-1.d-1) to SHR from 10 to 16 weeks of age. Male, age-matched untreated SHR (SHRc) and Wistar-Kyoto (WKY) rats served as controls. Systolic blood pressure (SBP) and vascular collagen contents were determined. Adventitia, media and lumen cross-sectional area, wall thickness of the aorta were assessed with computed video processing. Results: Compared with WKY rats, the SBP, vascular collagen contents, adventitia and media cross-sectional area and wall thickness were significantly increased in SHRc ( P <0.001), which were significantly reduced in treated SHR than in SHRc. There were no different in lumen cross-sectional area between each group ( P >0.05). Conclusions: In early stage of SHR, the major structural changes of aorta are the alternation of the vessel wall. Enalapril and losartan can effectively decreased blood pressure, improve vascular remodeling.
出处
《中国现代医学杂志》
CAS
CSCD
2000年第8期1-3,共3页
China Journal of Modern Medicine
