摘要
目的 :以低分子右旋糖酐为对照 ,观察降纤酶治疗急性缺血性脑血管病 (ICVD)的疗效及安全性。方法 :随机选择经头颅CT证实的急性ICVD 2 0 3例 ,分为 2组。降纤酶组 132例 ,给予降纤酶 10U ,溶于生理盐水2 5 0ml中静滴 ,qd× 3d ;对照组 71例 ,用低分子右旋糖酐 5 0 0ml静滴 ,qd× 10d。 结果 :降纤酶组和对照组总有效率分别为 89.3%与 6 3.4% (P <0 .0 1) ,降纤酶能显著降低纤维蛋白原 ,且无明显不良反应。结论 :降纤酶治疗急性ICVD疗效确切 ,明显优于低分子右旋糖酐。
Objectives:As stated in the title.Methods:203 Patients with CT confirmed ICVD were randomly divided to receive once daily 10U defibrase dissolved in 250 ml saline given by infusion for 3d ( n =132)or low molecular weight dextran solution 500 ml given by infusion ( n =71) for 10d.Results:The total effective rates obtained suggested that defibrase (89.3%)was obviously superior to that of low molecular weight dextran (63.4%)in treatment of ICVD with mild side effect.Conclusions:Defibrase is an effective and safety agent for treatment of ICVD.
出处
《中国新药杂志》
CAS
CSCD
2000年第8期560-562,共3页
Chinese Journal of New Drugs