摘要
目的:探讨玻璃体内注射贝伐单抗对伴有黄斑水肿的糖尿病患者眼血流参数的影响。方法:患者21例21眼,伴有弥漫性糖尿病性黄斑水肿(diabeticmacular edema,DME),黄斑中心厚度(central macularthickness,CMT)>320μm,无缺血性黄斑水肿或其他血管性视网膜疾病。患者术前以及注射1.25mg/0.05mL贝伐单抗1d,4wk后接受三种眼科检查:视力(visual acuity,VA)检测、光学相干断层扫描(optical coherence tomography,OCT)测量CMT以及采用超声成像测量眼动脉(ophthalmicartery,OA)、视网膜中央动脉(central retinal artery,CRA)、鼻侧睫状后动脉(nasal posterior ciliary artery,NPCA)以及颞侧睫状后动脉(temporal posterior ciliary artery,TPCA)中的收缩期峰值血流速度(peak systolic velocities,PSV)和舒张末期血流速度(end-diastolic velocities,EDV)。阻力指数(resistive indices,RI)由软件自动计算,注射前与注射后1d的血流速度进行了比较。患者术前和注射后4wk的VA和CMT值进行了比较。结果:注射前平均最佳矫正视力(best-corrected visual acuity,BCVA)为0.88±0.21logMAR,注射后为0.54±0.19logMAR(P<0.01)。平均CMT由注射前440.57±54.58μm下降至250.33±31.12μm(-190.24±36.00μm)。PSV、EDV和RI的变化并不显著。结论:贝伐单抗注射后视力显着改善,CMT降低,而PSV、EDV和RI在OA、CRA、TPCA和NPCA中没有显著变化。玻璃体内注射贝伐单抗注射液能改善VA和CMT,但对于糖尿病患者的OA、CRA、TPCA和NPCA的血流速度没有影响。
·AIM： To investigate effects of intravitreal bevacizumab on ocular blood flow parameters in diabetic patients with central macular thickness （CMT） 〉320μm and have no ischemic macular edema or other vascular retinal disease included to this study. All patients underwent three ophthalmologic examinations before and at one day and at 4 weeks after bevacizumab 1.25mg/0.05 mL injection. Examinations including visual acuity （VA）, measurement CMT by optical coherence tomography （OCT）, peak systolic velocities （PSV） and end - diastolic velocities （EDV） of blood flows were measured by ultrasound imaging in the ophthalmic artery （OA）, in the central retinal artery （CRA）, in the nasal posterior ciliary artery （NPCA） and temporal posterior ciliary artery （TPCA）.Resistive indices （RI） were automatically calculated by software of device. The velocities of blood flow before and one day after injections were compared. The values of patients before and 4 weeks after injections were compared for VA and CMT.· RESULTS： Mean best-corrected visual acuity （BCVA） was 0. 88 ±0. 21 logarithm of the minimum angle of resolution （IogMAR） before and after injection was 0.54±0.19 IogMAR units （P〈0.01）. Mean CMT decreased from 440.57±54.58 μm to 250.33±31.12 （-190.24±36.00） iJm. There were changes in the PSV, EDV and RI but this changes were not significant.·CONCLUSION： There was a significant improvement in VA and a decrease in CMT after bevacizumab injection.Regarding the PSV, EDV and RI, no observed significant changes in the OA, CRA, TPCA and NPCA after bevacizumab injection. Intravitreal bevacizumab injection improved VA and the CMT. However, it didn＇t affect blood flow velocities in diabetic patients on the OA, CRA, TPCA and NPCA.
出处
《国际眼科杂志》
CAS
2013年第3期425-428,共4页
International Eye Science
