摘要
目的探讨度洛西汀与马普替林治疗老年抑郁症的效果及对认知功能的影响。方法将60例老年抑郁症病人随机分为实验组和对照组,各30例,分别给予度洛西汀60~120mg/d和马普替林25~100mg/d治疗8周。于治疗前和治疗第1、2、4、8周末,采用汉密顿抑郁量表(HAMD)和事件相关电位P300进行抑郁状态和认知功能测定。结果治疗前两组HAMD评分差异无统计学意义(t=0.63,P>0.05),治疗1、2周末实验组HAMD评分较对照组下降,总分减分率较对照组高,差异有显著性(t=2.07~5.95,P<0.05);两组疗效比较差异无统计学意义(χ2=0.09,P>0.05)。治疗1周末两组P300电位差异无统计学意义(t=0.58~1.13,P>0.05);治疗8周末实验组P300电位N2、P3波潜伏期较对照组缩短,P3波幅较对照组升高,差异有显著性(t=1.99~2.34,P<0.05)。结论度洛西汀治疗老年抑郁症疗效与马普替林相当,但起效较快,且在改善老年抑郁症病人的认知功能方面明显优于马普替林。
Objective To study the effects of duloxetine and maprotiline on senile depression and cognitive function. Methods A total of 60 patients with senile depression were equally randomized to two groups: experimental group (duloxetine group) and control group (maprotiline group), who were treated with duloxetine (60-120 mg/d) and maprotiline (25 100 mg/ d), respectively, for eight weeks. The patients' depression state was assessed by Hamilton depression rating scale (HAMD) and their cognitive function by P300 potential, before treatment and at the end of weeks 1,2,4 and 8 of therapy. Results The diffe- rences of H AMDscore between the two groups, before treatment, were not statistically significant (t=0.63,P〉0.05). At the end of the first week and second week treatment, the HAM1) score in experimental group was lower than that in the control, and the score-reducing rate of total points was higher, being significant difference between the two groups (t- 2.07-5.95, P〈0.05). As compared with curative effect, no statistical difference was noted between the two groups (P〉0.05). The difference of P300 potential between the two groups at the end of the first week therapy was not statistically significant (t=0.58-1.13,P〉0.05), and at the end of eighth week, N2 and P3 latency shortened and P3 amplitude heightened in the experimental group versus the con- trol (t=1.99 2.34,P〈0.05). Conclusion Therapeutic effect of Duloxetine for senile depression is similar to maprotiline, hut the former has an advantage of rapid onset and improving cognitive function.
出处
《齐鲁医学杂志》
2013年第1期56-57,60,共3页
Medical Journal of Qilu
基金
青岛市医药卫生科研计划(2011-wazd086
2011-wszd083)
关键词
度洛西汀
马普替林
抑郁症
老年人
认知
duloxetine
maprotiline
depressive disorder
aged
cognation