摘要
根据小鼠的胸腺细胞实验数据 ,建立了描述胸腺细胞 (thymocyte)发育过程的数学模型 .该模型考虑了胸腺细胞与胸腺基质细胞 (thymicstromalcell,TSC)之间的相互作用 ,能够模拟CD4 - CD8- DN细胞重建动态及正常小鼠胸腺细胞的发育过程 .研究表明 ,模型中的一些参数应该是含有时间延迟的 .通过模型研究了胸腺细胞与TSC之间亲和力在胸腺选择过程中的阳性与阴性选择中的差异 .理论预言与实验数据基本一致 .
A mathematical model describing the thymocyte development is established. The reconstitution status of CD4 - CD8 - DN thymocytes and the development of thymocytes in normal thymus are explored introducing the interaction between thymocytes and thymic stromal cells. It is estimated that some of the parameters should be time delayed. The difference between the avidity parameters related to positive selection and negative selection is studied. The theoretical predictions can be compared with that provided by experimental results.
出处
《北京师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2000年第5期649-653,共5页
Journal of Beijing Normal University(Natural Science)
基金
国家自然科学基金资助项目!(39370 184)
关键词
胸腺基质细胞
数学模型
细胞重建
double negative thymocyte cell
reconstistution status
thymic stromal cell
mathematical model
