摘要
目的:研究尾加压素Ⅱ(UⅡ)与老年高血压患者颈动脉粥样硬化的相关性。方法:采用放免法测定130例老年高血压患者及72例健康老年人血浆UⅡ浓度,并使用颈动脉超声测定颈动脉内中膜厚度(IMT),根据IMT程度将高血压患者分为IMT0、IMT1、IMT2三组。结合UⅡ、IMT对各组进行比较和综合分析。结果:高血压组颈动脉粥样硬化发生率、IMT以及血浆UⅡ水平均显著高于健康对照组组(P<0.05或P<0.01);高血压患者血浆UⅡ水平随着IMT增厚程度的加重而升高,高血压分组三组之间UⅡ水平组间比较有显著性差异(P<0.01)。结论:血浆UⅡ水平升高与老年高血压患者动脉硬化发病密切相关。
Objective：To study the relationship between urotensinⅡ（UⅡ） and carotid athemsclemsis in elderly essential hypertension patients.Methods：One hundred and thirty elderly essential hypertension patients and seventy-two healthy old people were selected,the plasma concentration of UⅡwere measured with radioimmunoassay method,and B-mode uhmsound was used to measure carotid intima-media thickness（IMT）.The patients were divided into three groups（IMT0、IMT1and IMT2）according to the IMT.Combination of UⅡ,IMT of the group to carry out a comprehensive analysis and comparison.Results：Carotid atherosclerosis incidence、IMT and the level of plasma UⅡin essential hypertension patients were significantly higher than the health of the elderly（P0.05 or P0.01）.The level of plasma UⅡ increased with the severity of IMT.comparison between three groups with essential hypertension patients had the significance difference（P0.01）.Conclusion：The level of plasma UⅡ were closely correlated with atherosclemsis and plaque genesis in elderly essential hypertension parlents.
出处
《中国医药导刊》
2013年第1期46-47,共2页
Chinese Journal of Medicinal Guide
关键词
高血压
尾加压素Ⅱ
颈动脉硬化
Hypertension
UrotensinⅡ
Carotid athemsclemsis
