摘要
目的探讨重复经颅磁刺激(rTMS)治疗首发抑郁症的快速起效作用。方法将60例住院首发抑郁症患者随机分为研究组(药物合并rTMS治疗)30例和对照组(单纯药物治疗)30例。采用汉密尔顿抑郁量表(HAMD)在治疗前及治疗第1、2周末评定其临床疗效。结果治疗第1周末有效率研究组为40%,对照组为17%,两组比较有显著性差异(P<0.05)。第2周末有效率研究组为70%,对照组40%,两组比较仍有显著性差异(P<0.05)。两组HAMD评分较治疗前均有显著下降(P<0.01),研究组HAMD评分较对照组下降更显著(P<0.01)。结论抗抑郁剂合并rTMS治疗首发抑郁症起效迅速,值得临床推广应用。
Objective To explore the rapid effect of repetitive transeranial magnetic stimulation （rTMS） for patients with first-episode depression. Methods 60 patients with first-episode depression were randomly divided into study group （30 cases treated with antidepressant plus rTMS ） and control group （30 cases treated with antidepressant monotherapy）. The curative effect was assessed by using Hamilton Depression Scale （HAMD） at baseline and at the 1 st, 2nd weekend of the treatment. Results The curative effect at the 1 st weekend of the treatment in study group was significantly higher than that in control group （40% vs. 17%, P 〈 0.05 ）. Similar result was found at the 2nd weekend of the treatment （70% vs. 40%, P 〈 0.05 ）. Scores of HAMD in both groups decreased significantly at the 1 st, 2nd weekend when compared with the baseline （P 〈0.01 ）, the decrease of score of HAMD in study group was more obvious than that in control group （P 〈 0.01 ）. Conclusion Antidepressants in conjunction with rTMS have rapid effect for first-episode depression, which is worthy of clinical application.
出处
《精神医学杂志》
2013年第1期50-51,共2页
Journal of Psychiatry
关键词
首发抑郁症
重复经颅磁刺激
疗效
First-episode depression Repetitive transcranial magnetic stimulation （rTMS） Curative effect
