摘要
目的探索阿霉素(ADR)急性心肌损伤和1,6-二磷酸果糖(FDP)对该损伤防治作用的可能机制。方法将健康昆明小鼠48只,随机分成3组,即ADR组、FDP组和NS组。每组16只,雌雄各半。ADR组与FDP组均一次性腹腔注射ADR(30mg/kg),FDP组另外腹腔注射3次FDP[1100mg/(kg·次)],隔日1次,NS组注射等量生理盐水。结果用药至第6天,发现ADR组动物心肌组织中MDA含量升高,GSH含量降低,而FDP组这种变化幅度则较小。结论脂质过氧化反应的增强和机体抗氧化能力的下降参与了ADR急性心肌损伤;降低脂质过氧化反应程度和提高肌体的抗氧化能力,可能是FDP减轻ADR急性心肌损伤的机制之一。
Objection To explore the possibility mechanisms that adriamycin induces acute cardiac muscle injury and that FDP alleviate the cardiac muscle injury. Methods 48 healthy Kunming mice were divided into three groups randomly, viz. ADR group, FDP group and NS group. Each group consisted of 16 mice, and female and male accounted for half respectively. ADR group and FDP group were all injected ADR （30mg/kg） in abdominal cavity only once, and FDP group was injected FDP（ 1100mg/kg, time） three times （1 time every two days）,while NS group was only injected equal NS. Results On the sixth day of the experiment, the content of the MDA in the myocardium increased and that of the GSH decreased in ADR group, and those changes were slight in the FDP group. Conclusion The increase of peroxidation and the decrease of antioxidation maybe participated in the acute cardiac muscle injury caused by ADR. Moreover, the decrease of the peroxidation and the increase of antioxidation ability may be one of the mechanisms by which FDP can alleviate the cardiac muscle injury resulted from ADR.
出处
《中外医疗》
2013年第6期9-10,共2页
China & Foreign Medical Treatment
