摘要
目的观察心脉通胶囊治疗血脂异常合并颈动脉粥样硬化的临床疗效。方法按纳入标准选择2009年1月—2010年6月钦州市中医医院脑病科血脂异常合并颈动脉粥样硬化患者80例,将其随机分为治疗组41例和对照组39例。治疗组给予心脉通胶囊口服,对照组给予辛伐他汀片口服,均连续治疗6个月,治疗期间避免服用影响血脂代谢和抗动脉粥样硬化的其他药物。观察两组患者治疗前后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平以及颈动脉内膜中层厚度(IMT)和斑块面积、斑块总积分的变化。结果治疗6个月后,各组血清TC、TG、LDL-C水平降低,HDL-C水平提高,差异均有统计学意义(P<0.05);各组颈动脉IMT与斑块总积分显著减小,差异均有统计学意义(P<0.05)。两组患者治疗期间均未出现严重不良反应。结论心脉通胶囊具有调脂、抗动脉粥样硬化作用,与辛伐他汀片疗效相当,且安全性高,为临床提供新的用药选择,值得进一步研究。
Objective To observe the clinical effect of Xinmaitong capsule in the treatment of dyslipidemia associated with carotid atherosclerosis. Methods According to the inclusion criteria, January 2009 to June 2010 Qinzhou city department of encephalopathy hospital of traditional Chinese medicine blood lipid of 80 cases with carotid atheroselerosis in patients with abnormal, they were randomly divided into treatment group of 41 cases and control group of 39 cases. The treatment group was given Xinmaitong capsule orally, the control group was given simvastatin tablets, treated continuously for 6 months, during treatment to avoid the other drugs affecting lipid metabolism and atherosclerosis. Two groups were observed before and after treatment in patients with serum total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL- C） and high density lipoprotein cholesterol （ HDL - C） level and carotid IMT, total plaque score and plaque area. Results After 6 months of treatment, the serum concentrations of TC, TG, LDL- C level were significantly decreased, HDL- C levels increased significantly, the difference was statistically significant （P 〈 0. 05 ） ; each carotid IMT, total plaque score decreased significantly, the differences were statistically significant （ P 〈 0. 05 ）. Serious adverse reactions were not found in two groups of patients during treatment. Conclusion Xinmaitong capsule has anti -atherosclerosis effect of Tiaozhi, quite, efficacy and simvastatin tablets, and high safety, provide a new drug for clinical choice, worthy of further study.
出处
《实用心脑肺血管病杂志》
2013年第3期57-59,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
心脉通胶囊
血脂异常
颈动脉
动脉粥样硬化
治疗结果
Xinmaitong capsule
Dyslipidemias
Carotid arteries
Atheroselerosis
Treatment outcome
