摘要
目的:分析乙型肝炎相关慢加急性肝衰竭(HBV-related acute-on-chronic liver failure,HBV-ACLF)的死因,探讨引起HBV-ACLF死亡的独立危险因素.方法:回顾性分析乙型肝炎相关慢加急性肝衰竭患者127例的临床资料.以t检验筛选出有统计学意义的危险因素,再进行Logistic回归分析影响死亡的危险因素.结果:经单因素分析和多因素非条件Logistic回归分析结果显示,两组间血清总胆红素、血氨、血肌酐、血钠的差异有显著性(EXP值分别为1.025、1.063、0.611、1.047,均P<0.05).死亡组患者均死于多种并发症,其中,肝肾综合征27%、肝性脑病21%.结论:血清总胆红素、血氨、血肌酐是HBV-ACLF患者死亡的独立危险因素,血钠是独立保护因素.
AIM： To analyze the causes of death in patients with hepatitis B virus-related acute-on-chronic liver failure （HBV-ACLF） and discuss independent risk factors for death associated with HBVACLF. METHODS： Clinical data for 127 patients with HBV-ACLF were retrospectively analyzed. Univariate analysis was initially performed to identify significant factors affecting death in patients with HBV-ACLF. The identified significant factors were then included in multivariate and unconditioned Logistic regression analysis. RESULTS： Logistic regression analysis revealed that total bilirubin, blood ammonia, creatinine and blood sodium were significantly associated with death in patients with HBV-ACLF （EXP = 1.025, 1.063, 0.611, 1.047, all P 〈 0.05）. Patients often died from a variety of complications, including hepatorenal syndrome （27%） and hepatic encephalopathy （21%）.CONCLUSION： Total bilirubin, blood ammonia and creatinine are independent risk factors for death associated with HBV-ACLF, while blood sodium is an independent protective factor.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第6期537-540,共4页
World Chinese Journal of Digestology
