摘要
目的研究不同几何构型颈内动脉中的血流动力学因素,分析其构型和动脉狭窄的关系,为颈内动脉狭窄的风险预测和早期诊断提供一定的血流动力学基础。方法对两种常见形状的颈内动脉——U形和V形在定常流条件下的流场分别进行数值模拟和粒子成像测速的实验研究。结果在其中较上游的弯曲处,血流动力学因素与弯曲曲率存在单调的相关关系,V形在此处的狭窄风险小于U形。但是在下游的弯曲处,由于两个弯曲的叠加效应,其血流动力学因素与此处的曲率不存在单调的相关关系。结论弯曲动脉的曲率和动脉狭窄的风险成正相关关系。但是在连续多个弯曲的动脉中,则需考虑弯曲的叠加效应。对此叠加效应的研究有助于解释多弯血管内狭窄多发的原因。
Objective To investigate the hemodynamic factors in internal carotid arteries （ICA） with different shapes, and analyze the relationship between the arterial geometry and atherosclerotic stenosis to provide the hemodyanmic basis for the risk prediction and early diagnosis of ICA stenosis. Methods The flow field in the most two common types of ICAs, U and Vshaped ICA, were investigated by numerical simulation and particle image velocimetry （PIV） experiment under the condition of steady flow. Results At the upstream bend of ICA, the he modynamic factors were monotonically associated with the curvature of the bend. As a result, the risk for steno sis here was smaller in the Vshaped ICA, as compared to Ushaped ICA. But at the downstream bend, such monotonic relationship didn＇ t exist due to the synergistic effect of the two bends. Conclusions The curvature of the artery is positively related to the risk for stenosis, but the synergistic effect of bends needs to be considered for studying arteries with the serial bends. The research on the synergistic effect may explain why the stenosis is frequently observed in arteries with multiple bends.
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2013年第1期56-62,共7页
Journal of Medical Biomechanics
基金
虚拟现实技术与系统国家重点实验室开放课题,国家科技支撑计划项目(2012BAI19B04)
关键词
颈内动脉
动脉粥样硬化
血管狭窄
数值模拟
粒子成像测速
血流动力学
Internal carotid artery （ICA）
Atherosclerosis
Stenosis
Numerical simulation
Particle imagevelocimetry （PIV）
Hemodynamics
