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非小细胞肺癌中融合基因的研究进展

Research progress of fusion gene in non-small cell lung cancer
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摘要 非小细胞肺癌(non-small cell lung cancer,NSCLC)的分子靶向治疗是目前的研究热点,继EGFR、k-ras基因等靶点之后不断有新的肿瘤标志物被发现,本文将NSCLC中发现的ALK、ROS1、RET融合基因的研究进展及其在NSCLC中的临床、功能和结构特征进行阐述。 Molecular target therapy has become a hot research direction of NSCLC treatment, new tumor markers are continually found after EGFR and k-ras genes, The article reviews research progress of ALK/ROS 1/RET fusion genes in NSCLC and clinical/functional/structural characteristics of these fusion genes.
作者 田红霞 张绪超 吴一龙
机构地区 广东省医学科学院 广东省医学科学院
出处 《中国癌症杂志》 CAS CSCD 北大核心 2013年第2期149-154,共6页 China Oncology
基金 国家自然科学基金项目(No:81071699)
关键词 非小细胞肺癌 融合基因 靶向治疗 Non-small cell lung cancer Fusion gene Target therapy
分类号 R734.2 [医药卫生—肿瘤]
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参考文献30

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二级参考文献15

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中国癌症杂志
2013年 第2期

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