摘要
胃肠道间质瘤(gastrointestinal stromal tumor,GIST)是消化道最常见的间叶组织源性肿瘤,随着免疫组织化学、超微结构及分子生物学的发展,GIST成为近年来消化道肿瘤研究的热点之一。GIST常见发生于胃和小肠,以上腹部不适和腹部肿块、消化道出血为临床表现。内镜超声检查是敏感的检查方法,确诊需术后病理切片和免疫组化结果,CD117、CD34是最具特征的标志物。GIST对于传统的放、化疗不敏感,外科手术和分子靶向药物的治疗是GIST主要的治疗手段,其预后与肿瘤大小、分裂系数和肿瘤位置等有关。本文就GIST流行病学、临床诊断、治疗、预后的研究进展进行综述。
Gastrointestinal stromal tumor （GIST） is the most common tumors derived from mesenchymal tissue in diges- tive tract, With the development of immunohistochemical, uhrastructural and molecular biology, GIST has become one of the hot research of digestive tract tumor in recent years. GISTs occur in the stomach and small intestine commonly, and up- per abdominal discomfort, abdominal mass and gastrointestinal bleeding are main clinical manifestations. Endoscopic ultra- sonography is a sensitive screening method, and diagnosis confirmed by postoperative pathology and immunohistochemistry. CDll7 and CD34 are the most characteristic markers. GISTs are insensitive to chemotherapy and radiotherapy. Surgical and molecular targeted drug therapy are the primary treatments for GISTs, and its prognosis associated with tumor size, split factor and tumor location, and so on. The epidemiology, clinical diagnosis, treatment, and prognosis of GIST are reviewed in this article.
出处
《大连医科大学学报》
CAS
2013年第1期87-91,共5页
Journal of Dalian Medical University
关键词
胃肠道间质瘤
诊断
手术
gastrointestinal stromal tumor
diagnosis
operation
