摘要
能量代谢重编程是肿瘤的重要特征之一.快速增殖的肿瘤细胞以高速率的糖酵解为主要的供能方式,促进肿瘤对缺氧等应激环境的适应,增加肿瘤的恶性潜能.转录因子对糖代谢基因的调控是肿瘤能量代谢重编程的重要机制之一.低氧诱导因子1(hypoxia inducible factor-1,HIF-1),c-Myc,p53,NK-κB等作为调控糖代谢的主要转录因子影响糖酵解、三羧酸循环中相关基因的表达,同时糖代谢酶或产物也能反馈调节转录因子的活性.转录因子与糖代谢的相互作用关系为靶向代谢的抗癌药物的研究提供了新思路.
Reprogramming of energy metabolism has been established as a hallmark of cancer. Cancer cells demand significant energy to fuel cell proliferation. Moreover, to cope with stress such as hypoxia, cancer cells reprogram glucose metabolism by switching energy production from low-rate to largely high-rate glycolysis. This switch also increases the malignant potential. The key mechanisms underlying the glycometabolic switch involve transcription factors such as hypoxia-inducible factor-i, c-Myc, p53 and NF-κB. These transcription factors are crucial to regulate genes involved in glycolysis and the tricarboxylic acid cycle. Furthermore, metabolites and metabolic enzymes can provide feedback on the activity of glycometabolic-associated transcription factors. Therefore, elucidating the interactions between transcription factors and glucose metabolism could support anti-cancer drug development from the aspect of energy metabolism.
出处
《科学通报》
EI
CAS
CSCD
北大核心
2013年第5期419-425,共7页
Chinese Science Bulletin
基金
中国科学院“百人计划”(2006-067)
国家自然科学基金(40872168)资助
关键词
肿瘤
转录因子
糖代谢
cancer, transcription factor, glucose metabolism
