期刊文献+

制备高光学纯度的氯吡格雷硫酸氢盐的方法研究

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摘要 氯吡格雷是一种新型的具有不可逆性的抑制血小板聚集的噻吩并吡啶化合物。氯吡格雷右旋异构体具有血小板凝聚的抑制作用,而左旋异构体是无活性的。本文主要阐述对制备高光学纯度的氯吡格雷硫酸氢盐的方法研究。
出处 《海峡药学》 2013年第2期254-256,共3页 Strait Pharmaceutical Journal
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参考文献11

  • 1杨海玉,白金,李长波,张洪林,蒋林时.2-噻吩乙醇的合成技术及其在药物中的应用[J].化学与粘合,2007,29(6):435-438. 被引量:7
  • 2周林芳.氯吡格雷的合成路线研究[J].安徽医药,2006,10(8):614-616. 被引量:11
  • 3熊维..氯吡格雷的不对称合成工艺研究[D].广东药学院,2009:
  • 4陈子明,杜玉民,鲍春和,庄红林.氯吡格雷合成路线图解[J].中国医药工业杂志,2002,33(4):206-208. 被引量:27
  • 5Auber D, Ferrand C, Maffaand J E. Thieno [ 3,2-e J pyridine derivatives and their therapeutic application: US ,4529596 [ P]. 1985-07-16. 被引量:1
  • 6Alanin B, Daniel F. Dextm-rotatory enantiomer of methyl alpha-5 (4, 5,6,7 -tetrahydm ( 3,2 -c ) thieno pyr/dyl ) ( 2-chlorophenyl ) -acetate and the pharmaceutical compositions containing it: US4847265 [P]. 1989-07-11. 被引量:1
  • 7Michel B, Joel tL Process for the preparation of alpha-bromo-phenylac- eric acids: US ,5036156 [ P ]. 1991 -07-30. 被引量:1
  • 8Marcel D ,Joel R. Process for the preparation of an N-phenylacetic de- rivative of tetrahydrothieno[ 3,2-c] pyridine and it's chemical interme- diat: US,5204469 [ P]. 1993-04-20. 被引量:1
  • 9Bertrand C ,Jean-robert D Aldo P. Method for preparing 2-thienylethyl- unine derivatives: US,6080875 [P]. 2000-06-27. 被引量:1
  • 10Maria B, Marianna CN. Process for the preparation of a pharmacologi- cally active substance: US ,6180193 [P]. 2001-01-30. 被引量:1

二级参考文献51

  • 1姜丹.急性缺血性脑血管病早期诊断和对策[J].安徽医药,2005,9(8):624-626. 被引量:12
  • 2周卫平,吕淑敏.噻吩乙胺的合成及其在药物中的应用[J].医药化工,2005(11):28-31. 被引量:4
  • 3李平英,郭书印,方建新,成俊然.钠分散体的制备与应用研究[J].化学试剂,1996,18(4):234-236. 被引量:2
  • 4Lodewijk E, Khatri HN. 2-(2-Nitrovinyl) thiophene reduction and synthesis of thieno [3,2-c] pyridine derivatives[P]. EP:342118,1989-11-15. (CA 1990,112:235278s) 被引量:1
  • 5Bousquet A, Calet S, Heymes A. Isopropyl 2-thienyl glycidate, process for its preparation, and its use as synthetic intermediate for ticlodine and clopidogrel[P]. EP: 465358,1992-01-08.(CA 1992,116:194139j) 被引量:1
  • 6Aubert D, Ferrand C, Maffrand JP. Thieno[3,2-c] pyridine derivatives and their therapeutical use[P]. EP:99802,1984-02-01. (CA 1984,100:191856z) 被引量:1
  • 7Bouisset M, Radisson J. Process for the preparation of phenylacetic derivatives of thienopyridines[P]. EP:420706,1991-04-03.(CA 1991,115:114486m) 被引量:1
  • 8(SAN0FI. Preparation of d-α-5-(4,5,6,7-tetrahydro [3.2-c] thienopyridyl)-2-(chlorophenyl)acetic acid methyl ester as antithrombotic [P]. JP: 63203684,1988-08-23). CA 1989,110:192801w 被引量:1
  • 9Ueda Y, Nakayama H. A process for preparation of 4,5,6,7-tetrahydro[3,2-c]pyridine and its salts as an intermediate for an antiinflammatory, vasodilating agent and blood platelet aggregation inhibitor[P]. JP: 62103088,1987-05-13.(CA 1998,108:21871y) 被引量:1
  • 10Anne-Archard G, Heymes A, Valette G. 2-(Thienyl) ethyl amines and 2-(3-thienyl)ethyl amines[P]. EP:69002, 1983-01-05.(CA 1983,99:22305z) 被引量:1

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