摘要
目的分析儿童巨细胞病毒性肺炎（cytomegalovirus pneumonia，CMVP）病例的流行病学特征和临床表现，指导临床诊疗。方法采集2010年9月-2012年3月解放军第101医院收治的53例人类巨细胞病毒（human cytomegalovirus，HCMV）感染病例标本，检测HCMV-IgM、HCMV-IgG和HCMV—DNA。并利用描述性统计方法分析患者流行病学特征、临床表现以及影像学特点，应用直线相关分析患者发病年龄与病程的关系。结果患儿年龄以≤12个月为主（占92．4％），发病年龄和病程呈负相关。与对照组相比，CMVP患儿的淋巴细胞构成比明显高于对照组（X2=12．84，P〈0．05），CM—VP组血小板计数明显高于对照组（t=6．371，P〈0．05）。所有患儿CMV—IgG和CMV．DNA检测均为阳性。结论CMVP好发于年龄小于1周岁的儿童。患儿淋巴细胞比率和血小板计数异常增高。常出现咳嗽、气促、喘息、肺部哕音以及发热等症状、体征。
Objective To summarize the clinical features and provide a clue for clinical diagnosis of CMVP cases through analyzing the epidemiologic feature and laboratory test results. Methods 53 cases were collected by department of pediatrics of PLA 101 hospital from September 2010 to March 2012. The CMV-IgM,CMV-IgG,CMV-DNA of specimens were detected. Descriptive epidemiology was used to analyze their epidemiologic feature. Correlation analysis was used to analyze the relation between age of onset and pathogenesis. Results 92.4% of the cases were under 12 months. There is negative correlation between age of onset and pathogenesis. The lymphocyte ratio（x2 = 12.84, P 〈0.05） and PLT count （t = 6. 371, P 〈 0.05 ） of CMVP cases were higher than normal control group. HCMV-IgG and HCMV-DNA of the cases were all positive. Conclusions Most of the CMVP cases were below 1 year-old. Lymphocyte ratio and PLT count of the cases are high. Most of the patients appear cough, short breath, rale and fever.
出处
《国际病毒学杂志》
2013年第1期25-27,共3页
International Journal of Virology
关键词
巨细胞病毒性肺炎
儿童
诊断
Cytomegalovirus pneumonia
Children
Diagnosis
