摘要
目的:分析胰腺实性-假乳头状瘤病理肉眼观察、镜检及免疫组化表现,并探讨鉴别诊断方法。方法:收治胰腺实性-假乳头状瘤患者17例,回顾性分析病理形态及免疫组化临床资料。结果:活检肉眼见肿物直径2.7～13.8cm,平均直径6.5cm,其中12例有完整包膜,5例有部分包膜;光镜下肿瘤组织学表现主要为实性区、囊性区及假乳头区;免疫组织化学染色结果显示:肿瘤细胞Vimentin、α-CAT阳性17例,阳性率100.0%;CD10、β-catenin阳性14例,阳性率82.4%;PR阳性11例,阳性率64.7%;CK(pan)阳性8例,阳性率47.1%;Syn、CgA阳性3例,阳性率17.6%;S-100、EMA及ER均阴性。结论:作为一种胰腺低分化恶性肿瘤类型,实性-假乳头状瘤应根据临床症状、病理形态学改变及免疫组化综合诊断,并与其他肿瘤加以鉴别。
Objective： To analyze the pathological performance of naked eye, microscopic examination and immunohistochemica1 of solid -pseudopapillary tumor of pancreas,and investigate the methods of differential diagnosis. Methods：The clinieopathological, immunohistochemical features data of 17 patients with solid - pseudopapillary tumor of pancreas were retrospectively analyzed in the period form March 2008 to December 2011. Results：The mean diameter of these turmors was 6. 5cm with the range from 2. 7 - 13. 8cm including 12 patients with complete capsule and 5 patients with partly capsule. The main histology performance in light microscope included solid area, cystic area and fake nipple area. Immunohistochemistry showed that the positive rate of Vimentin and α- CAT was 100.0%, the one of CD10 and 13 - catenin was 82.4% , the one of PR was 64.7% , the one of CK （pan）was 47. 1% and the one of Syn and CgA was 17.6%. Conclusion：As a rare low - grade malignant tumor of pancreas, the diagnosis of solid - pseudopapillary tumor of pancreas need the clinical symptoms, pathological and morphological changes and immunohistochemical performance, and also significant for differential diagnosis with other tumors.
关键词
胰腺实性-假乳头状瘤
病理诊断
鉴别诊断
solid -pseudopapillary tumor ofpancreas
pathology
diagnosis
differentialdiagnosis
