摘要
建立了饮用水源水中6种磺胺类抗生素的固相萃取超高效液相色谱-串联质谱分析方法。优化了固相萃取、液相色谱、串联质谱多反应监测模式检测的相关参数;采用外标法定量,并对实际饮用水源水样品的基体效应进行评价。实验结果表明,目标化合物在1.0～100.0μg/L范围内线性关系良好,仪器检出限为0.03～0.54μg/L,实际水样的加标回收率60%～75%。该本方法灵敏度高,选择性好,外标法定量准确性较好,但实际样品存在一定的基体抑制效应。
A method of determination of 6 sulfonamide antibiotics （SAs） in drinking source water was developed using solid-phase extraction （SPE） and ultra performance tandem mass spectrometry （UPLC-MS-MS）. The parameters of SPE, UPLC, and MRM mode of tandem mass spectrometry were optimized. External standard method was used to quantify the target SAs and matrix effects of real environmental samples were assessed. Good linear regression results were obtained for most SAs in the range of 1.0-100.0 μg/L, and instrument detect limits for 6 SAs ranged from 0. 03 μg/L to 0. 54 μg/L. The recovery rates of drinking source water varied from 60% to 75%. A conclusion was reached that this method had high sensitivity, high selectivity and good accuracy. A certain extension of suppression matrix effect was observed in real samples.
出处
《中国环境监测》
CAS
CSCD
北大核心
2013年第1期98-102,共5页
Environmental Monitoring in China
基金
江苏省环境监测基金项目(1006)
