摘要
目的探讨肠外营养（PN）支持对乳腺癌术后化疗患者的营养状况、免疫功能的影响。方法将94例乳腺癌术后患者随机分为治疗组（47例）和对照组（47例）。所有患者给予CEF方案化疗，治疗组给予谷氨酰胺强化的PN支持治疗，对照组仅给予常规营养支持治疗。比较患者化疗前后营养指标、免疫指标的变化及不良反应。结果化疗后，治疗组的血清白蛋白（ALB）、前白蛋白（PA）及血红蛋白（Hb）水平较化疗前下降不明显（均P〉0．05），但对照组ALB、PA及HB水平较化疗前显著下降（均P〈0．05）；化疗后，两组CD4、CD8、CD4／CD8和IgA、IgG、IgM水平均较化疗前有所下降（均P〈0．05），而治疗组免疫指标水平均显著高于对照组（均P〈0．05）；两组均表现为恶心呕吐、腹泻及轻度骨髓抑制等不良反应，但对照组患者体质量减少（0．91±0．53）蚝，治疗组体质量增加（0．45±0．21）kg，差异有统计学意义（t=5．53，P〈0．05）。结论乳腺癌患者术后化疗期间给予PN治疗，可改善化疗患者的营养状况以及免疫功能，提高其对化疗的耐受性，从而提高疗效及改善预后。
Objective To explore the influence of parenterai nutrition（PN） on nutritional status and immune function in breast cancer patients undergoing postoperative chemotherapy. Methods 94 patients with breast cancer postoperative patients were randomly divided into the treatment group（47 cases） and the control group （47 cases）. All the patients were given chemotherapy with VBP. The treatment group was given glutamine fortified PN, and the control group was given normal nutrition support, respectively. The nutritional status and immune function before and after chemotherapy, and main toxieities were observed. Results Compared with those before chemotherapy, there were no significant decrease on the level of ALB ,PA and HB in treatment group（ all P 〉 0.05 ） ,while those indicators in con- trol group was significantly decreased（ all P 〈 0.05 ）. After chemotherapy, CD4, CDs , CDn/CDs and IgA, IgG, IgM lev- els of the two groups were lower than those before chemotherapy（ all P 〈 0.05 ）, and the levels of immune indicators of the treatment group were significantly higher than those of the control group（ all P 〈 0.05 ）. The main toxicities in two groups were nausea and vomiting, diarrhea and mild bone marrow suppression, and the body weight in control group decreased （0.91±0.53 ） kg, while it increased （0.45 ±0. 21 ） kg in treatment group （ t = 5.53, P 〈 0.05 ）. Conclusion PN treatment for breast cancer patients during chemotherapy can improve nutrition status and immune function, enhance the tolerance of chemotherapy, so as to improve curative effect and prognosis.
出处
《中国基层医药》
CAS
2013年第4期496-498,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
乳腺肿瘤
化学疗法
胃肠外营养
营养状况
免疫功能
Breast tumor
Chemotherapy
Parenterai nutrition
Nutritional status
Immune function
