摘要
抗菌肽是生物体内组成性或诱导性表达的一类小分子多肽,是机体防御系统的重要组成部分。抗菌肽不仅具有广谱杀菌能力,还具有抗真菌、抗病毒、抗寄生虫等生物活性。抗菌肽体外的抗炎作用已经研究较多,但其在体内的抗炎作用才逐渐引起学者的关注。抗菌肽对炎症的调节是多方面的,主要通过抑制生物性致炎因子的生长、调节炎症相关信号通路及其转录因子的表达、调节免疫活性以及中和LPS等,从而发挥抗炎作用。本文就抗菌肽在体内抗炎作用的研究进展作一综述。
Antimicrobial peptides （AMPs）, a family of small polypeptides which are produced by constitutive or inducible expression in organisms, are key components of host defense system. Besides broad-spectrumantibacterial activity, AMPs also have many biological activities against fungi, virus and parasites. The antiinflammatory action of AMPs in vitro has been studied widely, but their in vivo action attracts attention until now.AMPs regulate inflammation in vivo by many ways, such as regulating the expression of inflammation-related signaling pathways and transcription factors, inhibiting the growth of biological inflammatory cytokines, modulatingthe immune activity and neutralizing lipopolysaccharide （LPS）. In this paper, we summarized the anti-inflammatory action of AMPs in vivo.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2013年第3期260-263,共4页
Immunological Journal
基金
广东省战略新兴产业核心技术攻关项目(2012A080800016)
国家自然科学基金(81274061)
广州市番禺区科技计划项目基金(2010-专-12-3)资助
关键词
抗菌肽
炎症因子
炎症信号通路
免疫调节
脂多糖
Antimicrobial peptides
Inflammatory cytokines
Inflammatory signaling pathways
Immunomodulation
Lipopolysaccharide
