摘要
目的:探讨老年2型糖尿病(T2DM)患者血清超敏C反应蛋白(hs2CRP)水平与动脉硬化的相关性。方法:选择T2DM患者60例,分为糖尿病斑块组30例(超声检查颈内动脉见斑块)和糖尿病非斑块组30例(超声检查颈内动脉未见斑块),对照组健康体检者30例,检测空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C)和hs2CRP。结果:糖尿病斑块组与非斑块组患者的FPG、HbA1c、TC、TG、LDL-C水平均明显高于正常对照组(P<0.05),HDL-C低于对照组(P<0.05);三组间的hs2CRP差异有统计学意义(P<0.05),斑块组hs2CRP水平高于非斑块组,且均高于正常对照组(P<0.05)。结论:hs2CRP与老年T2DM患者颈动脉硬化的发生有密切相关性,在老年T2DM颈动脉硬化的发展中起重要作用。
Objective： To investigate the association between serum high-sensitivity C-reactive protein （ hs2-CRP ） level and large arterial elasticity in patients with type 2 diabetes （ T2DM ） .Method： 60 T2DM were divided into two group： 30 patients with atherosclerosis disease, 30patients without atherosclerosis disease, and 30 healthy volnuteers were selected as control group, hs2CRP, body mass index （ BMI ）, triglyceride （ TG ）, total cholesterol （ TC ）, Highdensity Lipoprotein2cholesterol （ HDL2C ）, low density lipoprotein2 cholesterol （ LDL2C ）, glycosylat2ed hemoglobin （ HbAlc ） and fasting plasma glucose （ FPG ） were measured.Result： hs2CRP was significantly increased in T2DM group as compared with control levels.Hs2CRP was significantly increased in T2DM with atherosclerosis disease as compared with that inT2-DM without atherosclerosis group （ P〈0.05 ） .Univariate analysis implied that hs2CRP level in diabetes mellitus waspositively related with HbAlc, TC, TG, LDL-C （ P〈0.05 ） .Hs2CRP was negatively correlated with HDL-C （P〈0.05） .But there was no relationship between hs2CRP and BMI, FPG （P〈0.05） .Conclusion： Increase in Hs2CRP is closely correlated with atherosclerosis disease in type 2 diabetes mellitus, suggesting that hs2CRP plays an important role in risk prediction of the T2DM patients with atherosclerosis disease.
出处
《中国医学创新》
CAS
2013年第4期9-10,共2页
Medical Innovation of China
关键词
超敏C反应蛋白
2型糖尿病
颈动脉硬化
Hypersensitivity C2-reactive protein
Type2 diabetes
Atherosclerosis disease
