摘要
目的研究职业对中国女性乳腺癌患者的临床病理特征、临床检查的实施以及治疗模式选择的影响。方法连续收集2003年2月至2004年1月西安交通大学医学院第一附属医院收治的484例女性乳腺癌病例,收集患者的相关信息,采用卡方检查和秩和检验的统计学方法比较不同职业人群在临床病理特征、临床检查实施和治疗模式方面的差异。结果不同职业的人群在肿瘤大小、pTNM分期、术前钼靶检查、术后ER、PR、Her2检测、外科手术方式及是否接受化疗方面均存在统计学差异(P<0.05),具体表现为经济收入越高的职业就诊时肿瘤分期越早,相关临床检查的实施率越高,对外科微创手术方式及化疗的接受率也越高。结论职业收入越低的女性乳腺癌患者就诊时肿瘤分期更晚、相关临床检查的实施率更低、保乳手术和化疗的实施率更低。
Objective To explore the impacts of female patients＇ occupation on clinicopathological characteristics and treatment patterns of breast cancer in China. Methods We collected 484 breast cancer cases in succession between Febru- ary 2003 and January 2004 treated in the First Affiliated Hospital, Medical School of Xi＇an Jiaotong University. The differences in distribution of variables, including clinicopathological characteristics and treatment patterns between different occu- pation groups, were examined using Mantel-Haenszel Chi-square tests and rank sum tests to obtain P-values for the test of no-association. Results Various occupation groups differed significantly in such variables such as tumor size, pTNM stage, mammography examination, postoperative ER, PR and Her2 detections, operation mode, and choice of chemotherapy （P〈.05）. To be specific, with the increase of occupational income, the tumor stage at diagnosis was earlier, implementation rate of clinical examinations was higher, and acceptance rate of minimally invasive operation and chemotherapy was higher too. Oonclusion The more advanced breast cancer is, the lower implementation rate of clinical examinations and more negative attitude towards minimally invasive operation as well as chemotherapy are seen in occupational low-income female population.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2013年第2期218-223,共6页
Journal of Xi’an Jiaotong University（Medical Sciences）
关键词
乳腺癌
职业
临床病理
治疗模式
女性
肿瘤分期
breast cancer
occupation
clinicopathology
treatment pattern
female pTNM stage
