摘要
目的:探讨枸杞多糖对肥胖大鼠肾脏的保护作用及其机制。方法:制备肥胖大鼠模型,枸杞多糖连续灌胃12周,测定血清TC、TG、HDL、LDL、FBG、FINS、Cr、BUN及肾脏LDL与Ox-LDL,并计算ISI。结果:枸杞多糖具有降脂、降糖、改善胰岛素抵抗、改善肾功能、降低肾脏组织LDL与Ox-LDL的作用。结论:枸杞多糖对肥胖大鼠肾脏具有一定的保护作用,其机制可能与减少肾脏组织Ox-LDL有一定的关系。
Objective ： To investigate the protective effect of kidney and mechanism of LBP in obese rats. Methods ： LBP continuous gavage for 12 weeks in obese rats, then serum levels of TC, TG, HDL, LDL, FBG, FINS, Cr, BUN and kidney LDL, Ox - LDL were all determined, and the ISI was calculated. Results：LBP could lower lipid and blood glucose, and improve insulin resistance,improve kidney function, reduce the role of the kidney tissue LDL and Ox - LDL. Conclusion： LBP had a protective role for kidney in obese rats and its mechanism might be associated with reducing kidney tissues of Ox - LDL.
出处
《中华中医药学刊》
CAS
2013年第2期397-398,共2页
Chinese Archives of Traditional Chinese Medicine
关键词
枸杞多糖
肥胖大鼠
肾脏
Ox—LDL
Lycium Barbarum Polysaccharide （LBP）
obese rats
kidney
Ox - LDL
