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不同类型左旋门冬酰胺酶的特点及临床应用 被引量:6

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摘要 1 左旋门冬酰胺酶(L-Asp)的基本作用L—Asp是急性淋巴细胞白血病(ALL)治疗方案中不可缺少的药物。1953年Kidd等发现输豚鼠血浆能使大鼠和小鼠淋巴瘤缩小,随后发现其抗淋巴瘤作用是由于含有L—Asp。L—Asp也可产自细菌,但只有源自大肠杆菌和欧文菌的有较好的抗ALL活性,利用这些细菌更易大批量生产和纯化L-Asp。1960年代后期已有L—Asp治疗白血病的临床报道。
作者 罗学群
出处 《中国小儿血液与肿瘤杂志》 CAS 2013年第1期1-4,共4页 Journal of China Pediatric Blood and Cancer
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