摘要
目的:探讨中国汉族抑郁症患者5-羟色胺2A(5-HT2A)受体基因rs6311多态性与抗抑郁药物疗效的关系。方法:对符合美国《诊断与统计手册:精神障碍》第四版(DSM-IV)重性抑郁障碍诊断标准的121例抑郁症患者予以艾司西酞普兰或帕罗西汀治疗,疗程6周。采用高温连接酶检测反应法(LDR)检测5-HT2A受体基因rs6311位点,分析其与抗抑郁药物疗效的关系。结果:①5-HT2A受体基因rs6311位点T等位基因、TT基因型在无效组的频率显著高于有效组(P<0.05)。②携带rs6311位点TT基因型患者的汉密尔顿抑郁量表(HAMD)减分值和减分率均显著低于携带CC基因型患者(P<0.05)。结论:5-HT2A受体基因rs6311位点多态性可能与5-羟色胺再摄取抑制剂(SSRIs)疗效有关,T等位基因、TT基因型可能为疗效差的预测因子。
Objective： To investigation the association between 5-HT2A receptor gene rs6311 polymorphism and antidepressants treatment response of the Han nationality in China. Methods： 121 major depressive disorder patients who met DSM-IV criterion were given antidepressant drugs for six weeks （escitalopram,paroxetine）. 5-HT2A receptor gene rs6311 polymorphism was genotyped by the ligase detection reaction. Results： ①The frequencies of T allele and Tr genotype of rs6311 were higher in non-responder group than that in responder group（P〈0.05）.②The HAMD decreasing score and decreasing score rate of the patients with Tr genotype of rs6311 were lower than those with CC genotype of rs6311 （P〈0.05）. Conclusion： The rs6311 of 5-HT2A receptor gene may be related with the treatment response to SSRIs. T allele and TT genotype is likely to be a predictive factor of the worse treatment response to SSRIs.
出处
《中国临床心理学杂志》
CSSCI
CSCD
北大核心
2013年第1期51-53,共3页
Chinese Journal of Clinical Psychology
基金
国家十五攻关课题(2004DA7210A21)
