摘要
目的评价T淋巴细胞毒相关抗原4（CTLA4）基因49位点多态性与中国人Graves病（GD）的相关性。方法检索中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）、万方数据库，收集CTLA4基因49位点多态性与GD相关性的文献。检索时间为2000年1月1日至2010年9月20日。用Meta分析检测CTLA4基因49位点的基因型和等位基因在GD组与对照组中是否有差异。结果共纳入6篇文献，GD570例，对照组486例。根据各项研究的异质性检验结果，均利用固定效应模型对CTLA-4基因49位点的AG、GG、GG＋AG基因型和G等位基因与GD相关性进行Meta分析，各项研究的合并OR值（95％CI）分别为1．97（1．37～2．82）、3．66（2．42～5．53）、2．55（1．82—3．58）、1．99（1．49～2．65）。结论CTLA4基因49位点多态性能增加中国人群发生GD的风险。
Objective To summarize the correlation between cytotoxic T lymphocyte associated antigen-4 （CTLA-4） promoter-49 A/G polymorphism and Graves＇ disease （ GD ） in China. Methods The publications be- fore Sep. 30, 2011 about the correlation between CTLA-4 promoter-49 A/G polymorphism and GD in China were collected by searching CNKI, CBM, and Wanfang database. Meta-analysis was performed to check the difference of genotypes such as AG, GG, GG ＋ AG, and G allele between GD group and the control group. Results A to- tal of 6 studies involving 570 cases in GD group and 486 cases in the control group were included in the recta-a- nalysis. According to the heterogeneity of these studies, meta-analysis was performed to analyze the correlation between AG, GG, GG ＋ AG genotype, G allele and GD by fixed effects model. The pooled OR value（95% CI） of various studies was 1.97 （ 1.37 - 2. 82）, 3.66 （ 2. 42 - 5.53 ） , 2. 55 （ 1.82 - 3.58 ） , and 1.99 （ 1.49 - 2. 65 ）. Conclusion The meta-analysis demonstrates that CTLA-4 promoter-49 A/G polymorphism increases the possibility of getting GD in Chinese.
出处
《中华内分泌外科杂志》
CAS
2013年第1期64-68,共5页
Chinese Journal of Endocrine Surgery
