摘要
目的调查2010年7所精神疾病专科医院住院精神分裂症患者抗精神病药(APD)使用现状。方法以2010年7月12至14日为时点调查日,对全国5省市7所精神疾病专科医院的1024例精神分裂症住院患者使用自制调查表进行APD使用的现况调查。结果 (1)1024例患者中,男652例(63.7%),女372例(36.3%)。(2)1010例(98.6%)患者接受了APD治疗,药物使用频率依次为:利培酮378例次(36.9%)、氯氮平295例次(28.8%)、奎硫平118例次(11.5%)、阿立哌唑101例次(9.9%)、氯丙嗪78例次(7.6%)齐拉西酮64例次(6.3%)、奋乃静59例次(5.8%)、奥氮平59例次(5.8%)、舒必利56例次(5.5%)。(2)非典型APD的使用频率为87.7%;典型APD的使用频率为22.8%;3.03%的患者接受了长效药物治疗。(3)72.36%的患者接受了单一抗精神病药治疗;26.27%的患者联合使用2种或2种以上APD。(4)合用药物主要是抗胆碱能药(25.00%)、苯二氮类药物(20.61%)、β-受体阻滞剂(19.34%)和心境稳定剂(11.72%),主要用于控制不良反应或增效治疗。结论非典型APD已经成为我国治疗精神分裂症的主流药物,APD的使用比较合理规范,但尚有不足。
Objective To investigate the antipsychotic drug （APD） use patterns for treating inpatients schizophrenia. Method Seven psychosis hospitals were involved. The investigation was conducted during 12th 14th, July, 2010, using the revised self- compiled questionnaire. Results Among the total of 1024 inpatients, male patient 652 （63.7%）, female patient 372 （36. 3% ） APD most frequently prescribed was risperidone （36. 9% ）, subsequently were clozapine （28.8%）, quetiapine （11.5% ）, aripiprazole （9. 9% ）, chlorpromazine （7. 6% ）, ziprasidone （6. 3% ）, perphenazine （5.8%）, Olanzapine （5.8%） and sulpiride （5.5%）. 87.7% the patients were treated with atypical APD （while 22. 8%with typical drugs）, in which 72. 36% with mono- pharmacy, 26. 27% of the patients were treated with 2 or more than 2 types of APD, and the percentage of patients with depot antipsychotics was 3.03%. The common concomitant medications were anticholinergic agents, Benzodi- azepine, β- receptor blockade, mood stabilizers and antidepressants, in order to control the adverse effects or augment the efficacy of APD. Conclusion Atypical drugs are the mainstream to treat schizophrenia, The use patterns of APD on psychiatric inpationts was normal basically, but Inappropriate use too.
出处
《国际精神病学杂志》
2013年第1期14-17,共4页
Journal Of International Psychiatry
关键词
精神分裂症
抽样调查
抗精神病药
Schizophrenia
Sampling investigation
Antipsychotic drugs
