摘要
目的观察表皮生长因子受体2(HER-2)及凋亡抑制蛋白Survivin在胃癌组织中的表达,探讨其与临床病理的相关性及其临床意义。方法使用免疫组织化学法检测2002-2011年江苏盛泽医院79例未经放、化疗的胃癌患者组织中HER-2及Survivin蛋白的表达。并分析两者与胃癌患者临床病理学参数之间的关系。结果 79例胃癌患者,男女比例为2.59:1,中位年龄为67岁,HER-2蛋白在胃癌中的阳性表达与肿瘤分化程度、Lauren分型、淋巴结转移及临床分期相关(p<0.05),与性别、年龄、肿瘤直径、浸润深度不相关。Survivin与肿瘤分化程度相关(p<0.05),与性别、年龄、肿瘤直径、Lauren分型、浸润深度、淋巴结转移及临床分期不相关。HER-2在Survivin阳性的表达率(70.59%)明显高于在Survivin阴性表达组(9.09%()P<0.05)结论胃癌HER-2蛋白的阳性表达与肿瘤分化程度、Lauren分型、淋巴结转移及临床分期相关,可用于指导临床用药;Survivin表达可作为判断胃癌恶性程度和预后的重要指标,其与HER-2表达正相关,可促进胃癌细胞增殖。
Objective To observe the expression of human epidermal growth factor receptor 2（HER-2） and inhibitor of apoptosis protein （survivin） in gastric cancer tissue and analyze the correlation of expression and the clinical pathology. Methods Immunohistochemistry assay was used for detection of HER2 and survivin protein expression in 79 cases without radiotherapy and chemotherapy for gastric cancer patients from 2002 to 2011 in the Shengze Branch of Jiangsu Province Hospital.. XI--test was used to analyze the relationship between HER-2 and survivin expression with clinical pathological parameters and significance. Results In 79 gastric cancer patients, the male and female ratio was 2.59：1, while the median age was 67 years old. The expression of HER-2 expression was correlated with tumor differentiation, Lauren typing, lymph node metastasis and clinical staging, but not with sex, age, the diameter of tumor and depth Of invasion. Survivin was correlated with tumor differentiation, but not with sex, age, the diameter of tumor, Lauren typing, depth of invasion, lymph node metastasis and clinical staging. Correlation analysis of HER2 and survivin expression, HER2 was significantly higher in positive expression rate of survivin （70.59%） than in group negative for survivin （9.09%,p〈0.05）. Conclusion The positive expression of HER2 protein in gastric cancer correlates with tumor differentiation, Lauren typing, lymph node metastasis and clinical staging, so that it may guide the clinical treatment and improve the survival rate of patients. The expression of survivin is important for judging the malignancy and prognosis and it correlates with the expression HER2 and promotes the proliferation of gastric cancer cells
出处
《中国热带医学》
CAS
2012年第12期1516-1518,共3页
China Tropical Medicine
