摘要
目的探讨CT引导下经皮穿刺^125I粒子植入治疗肺转移癌的临床应用价值及安全性。方法27例肺转移癌患者中肝癌肺转移18例（46个结节），前列腺癌肺转移4例（9个结节），乳腺癌肺转移5例（12个结节）。共67个结节，结节直径0．5～4．0（平均2．1）cm。在cT定位下植入^125I粒子2～33粒／例，粒子活度为18．5～29．6MSq／粒，肿瘤匹配周边吸收剂量为90—120Gy，术后进行验证和质量评估。结果随访4个月，67个结节中CR24个，PR30个，NC5个，PD8个，总有效率达80．6％（54／67）。11例次出现不同程度气胸，其中3例次较重，术中胸腔穿刺后好转，较轻者密切随诊观察直至气体吸收；4例次出现痰中带血，对症处理后好转。结论CT引导下经皮穿刺125 I粒子植入治疗肺转移癌疗效肯定。CT定位准确，安全性较高。
Objective To explore the clinical application and safety of treatment of percutaneous radioactive 125I seed implantation treatment in lung metastases under CT guidance. Methods Twenty-seven lung metastatic malignancy cases （67 nodules） were studied. Eighteen cases （46 nodules ） were hepatic cancer, 4 cases （9 nodules） were prostate cancer, and 5 cases （12 nodules） were breast carcinoma. Diameters of lung nodules ranged from 0.5 cm to 4.0 cm with an average diameter of 2.1 cm. 125I seeds were embedded under CT guidance, using 2 to 33 particles/nodule with an activity of 18.5 to 29.6 MBq/grain for each particle. Tumor matched peripheral dose was 90 - 120 Gy. Postoperative validation and quality evaluation followed. Results Four months later, 24 nodules showed CR, 30 showed PR, 5 showed NC and 8 showed PD. The total effective rate was 80.6% （54/67）. In the course of treatment, 11 patients had pneumothorax, 3 had heavy lung compression and 4 had hemoptysis. All conditions were improved by pleural puncture or under close follow-up observation. Conclusion 125I seed implantation is an effective and safe technique in treatment of metastatic lung tumors under CT guidance.
出处
《中华核医学与分子影像杂志》
CSCD
北大核心
2013年第1期46-48,共3页
Chinese Journal of Nuclear Medicine and Molecular Imaging
