摘要
目的对超声内镜引导下细针穿刺（EUS—FNA）获得标本进行细胞学及组织学分析，并对两者进行初步比较。方法对2010年10月至2012年1月间经CT检查发现纵隔病变、腹膜后病变及胰腺病变的43例病例，予EUS-FNA取病理明确诊断，穿刺针为22G活检针，操作时无病理科医生在场。穿刺获得的组织条置于福尔马林液中，剩余部分涂片，分别进行细胞学及组织学检查。结果43例病例中，纵隔病变9例，腹膜后病变1例，胰腺占位30例，胰腺头部肥大2例，全胰腺肥大1例。细胞学诊断恶性22例，可疑恶性2例，少量异形细胞3例，未见瘤细胞16例；组织学诊断恶性肿瘤30例，可疑恶性I例，结节病2例，慢性炎症10例。细胞学的阳性率、敏感度及准确度分别为51％、59％、65％，组织学的阳性率、敏感度及准确度分别为74％、81％、84％，2组间差异有统计学意义（P〈0．05）。结论EUS—FNA组织学诊断的阳性率、敏感度及准确度均优于细胞学诊断。
Objective To evaluated diagnosis yield of cytological and histological analysis of endo- scopic ultrasound guided fine needle aspiration （EUS-FNA）. Methods A total of 43 patients who were clinically diagnosed as having mediastinal lesions, retroperitoneal lesions or pancreatic lesions by CT were re- cruited to the study. EUS-FNA was performed with standard 22G needle. Specimens were placed in formalin for histological analysis, and residual materials were prepared for cytologic analysis. Results Lesions were located in the mediastinum （ n = 9 ） , the retroperitoneum （ n = 1 ） , and pancreas （ n = 33 ）. Cytologic diagno- ses included malignancy （ n = 22 ） , suspicious malignancy （ n = 2 ） , atypical cell （ n = 3 ） , absence of malig- nancy （ n = 16）. Histologic diagnoses included malignancy （ n = 30）, suspicious malignancy （ n = 1 ）, sar- coidosis （ n = 2） , chronic inflammation （ n = 10）. The positive rates, sensitivities and accuracies of cytology and histology were 51%, 59% , 65% and 74% , 81% , 84% , respectively. Conclusion The positive rate, sensitivity and accuracy of histology of EUS-FNA is superior to cytology.
出处
《中华消化内镜杂志》
2013年第2期79-82,共4页
Chinese Journal of Digestive Endoscopy
