摘要
目的:研究不同糖代谢状态下糖化血红蛋白(HbA1c)与冠心病的相关性。方法:选择2010年6月至2011年10月,北京安贞医院心内科拟诊冠心病住院患者644例,收集临床资料,检测空腹血糖、HbA1c。行口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)测定餐后2h血糖(2hPG)。完成选择性冠状动脉造影术(coronary angiography,CAG)。以冠状动脉病变支数评价冠状动脉病变严重程度,按冠状动脉造影结果分为冠状动脉阳性组与冠状动脉阴性组。对比主要的糖代谢指标。按照OGTT结果分为NGT、IGR及DM 3组,分别研究HbA1c与冠状动脉病变相关性。结果:①冠状动脉阳性组HbA1c较冠状动脉阴性组明显升高[(6.42±1.09)vs.(5.92±0.86)%,P<0.01]。在冠状动脉阳性组中,HbA1c水平与随着冠状动脉病变支数增加而升高;②NGT组HbA1c与冠状动脉阳性及冠状动脉病变支数存在正相关,相关系数r分别为0.414及0.378,P<0.01。在IGR及DM组未见相关。结论:在糖代谢正常的冠心病高危人群中,HbA1c也可能与冠心病的发生及冠状动脉病变程度相关。
Objective：To investigate the association of glycated hemoglobin（HbAlc） and coronary heart disease in the different glucose metabolic states.Methods： A total of 644 hospitalized patients with suspicious coronary heart disease was selected in Anzhen hospital.Clinical data have been collected,HbA1c concentrations,fasting glucose（FBG）,postload glucose（PPG）,were measured.Coronary angiography was performed in all patients.According to the results of CAG,the 644 patients were divided into two groups： CHD group and non-CHD group as control.Results： HbA1c concentrations in the patients of the CHD group were significantly higher than that in the patients of the control group.HbA1c concentrations increased with the increasing number of diseased coronary branches.The incidence of CHD increases with the rise of HbA1c level.Conclusion： 1.In NGT group,HbA1c may also be associated with the occurrence of coronary heart disease.2.HbA1c ≥ 5.6%,coronary heart disease incidence of non diabetic patients may be significantly elevated.
出处
《心肺血管病杂志》
CAS
2013年第1期53-56,共4页
Journal of Cardiovascular and Pulmonary Diseases
关键词
糖化血红蛋白
糖尿病诊断标准
冠心病
危险因素
冠状动脉造影
Glycated hemoglobin
Diabetes diagnosis criteria
Coronary heart disease
Risk factors
Coronary angiography
