摘要
目的:分析腹腔积液标本病原菌分布及耐药状况,为临床合理使用抗菌药提供依据。方法:对2008～2010年陆床送检的腹腔积液标本的细菌学和药敏试验资料进行回顾性分析。结果:641例腹腔积液标本共检出病原菌118例(18.4%),革兰阴性(G^-)菌75株(63.6%),其中大肠埃希菌24株(20.3%),肺炎克雷伯菌18株(15.3%);革兰阳性(G^+)菌35株(29.7%),其中金黄色葡萄球菌12株(10.2%);真菌8株(6.8%)。G^-菌对阿米卡星、头孢他啶、头孢吡肟、亚胺培南、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦敏感率均大于90%,其他抗菌药呈现不同程度的耐药。G^+菌对万古霉素、替考拉宁和替加环素敏感较高。结论:以大肠埃希菌为代表的G^-菌是本院腹腔感染主要病原菌,耐药严重,应加强腹腔积液标本的细菌学检查,合理使用抗菌药。
Objective：To analyze the distribution of pathogens and antibiotics sensitivity in patients with seroperitoneum to provide reference for reasonable application of antibiotics in clinics.Methods：A retrospective analysis was conducted for data of pathogens and antibiotics sensitivity in seroperitoneum collected in our hospital from Jan 2008 to Dec 2010.Results：118 pathogens from 641 seroperitoneum specimens collected were acquired.Among them,63.6%（75/ 118） were gram-negative,29.7%（35/118 ） were gram-positive and 6.8%（8/118） were fungus.The top three species included Escherichia coli（20.3%）,Klebsiella pneumonia（15.3%）,and Staphylococcus aureus（10.2%）.Against gram-negative bacillus,antimicrobial agents with more than 90%susceptibility included amikacin,ceftazidime,cefepime, imipenem,cefoperazone-sulbactam,and piperacillin-tazobactam.All gram- positive cocci were susceptible to tigecycline, vancomycin and teicoplanin.Conclusion：The main intra-abdominal causing pathogens are gram-negative bacilli,especially enterobacteriaceae.The drug resistance presents a serious situation.
出处
《药物流行病学杂志》
CAS
2013年第1期15-17,共3页
Chinese Journal of Pharmacoepidemiology
关键词
腹腔积液
病原菌
抗菌药
耐药性
Seroperitoneum
Pathogen
Antibiotics
Resistance
