重症监护病人口腔护理使用氯已定对呼吸机相关性肺炎发生率的影响被引量：36

重症监护病人口腔护理使用氯已定对呼吸机相关性肺炎发生率的影响

下载PDF

导出

摘要目的对文献进行系统评价,以明确危重病人口腔护理使用氯已定对预防ICU病人呼吸机相关性肺炎的有效性。方法据Cochran协作网制定的策略,并使用PubMed和Medline数据库进行英文检索,对符合检索条件的文献进行系统评价,文献质量评价和数据提取由2名操作员独立完成,使用RevMan 5.0软件进行分析,以相对危险度(RR)值或者加权均数差(WMD)的95%可信区间(95%CI)作为统计结果。结果共有11篇随机对照临床试验(RCT)的文献,共2 583例患者纳入研究。分析结果显示:口腔护理中使用抑菌剂氯已定,能显著降低VAP的发生(RR=0.74,95%CI=0.60～0.91,P=0.004),缩短机械通气时间(WMD=-2.67,95%CI=-4.48～-0.85,P=0.004)。结论口腔护理使用氯已定,能有效预防重症监护病人呼吸机相关性肺炎的发生。

作者安园园汪惠才马龙王梅新

机构地区新疆医科大学第一附属医院特需综合内科

出处《护士进修杂志》 2013年第3期263-265,共3页 Journal of Nurses Training

基金新疆医科大学第一附属医院管理专项基金(编号:2009-GL-5)

关键词口腔护理氯已定呼吸机相关性肺炎 META分析 Oral care Chlorhexidine Ventilator-associated pneumonia meta-analysis

分类号 R472 [医药卫生—护理学] R563.1 [医药卫生—临床医学]

引文网络
相关文献

参考文献10

1马龙,李娜,吴昆,安园园,张庭荣.重症颅脑损伤患者呼吸机相关性肺炎危险因素与病原菌分析[J].中华医院感染学杂志,2012,22(2):261-263. 被引量：22
2Fourrier F,Dubois D,Pronnier P. Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit:A double-blind placebo-controlled multicenter study[J].Critical Care Medicine,2005.1728-1735. 被引量：1
3DeRiso AJ,Ladowski JS,Dillon TA. Chlorhexidine gluconate 0.12％ oral rinse reduces the incidence of total nosocomial respiratory infection and nonprophylactic systemic antibiotic use in patients undergoing heart surgery[J].Chest,1996.1556-1561. 被引量：1
4Fourrier F,Cau-Pottier E,Boutigny H. Effects of dental plaque antiseptic decontamination on bacterial colonization and nosocomial infections in critically ill patients[J].Intensive Care Medicine,2000,(9):1239-1247. 被引量：1
5Jadad AR,Moore RA,carrou D. Assessing the quality of reports of randomized clinical trials:Is blinding necessary[J].Controlled Clinical Trials,1996.1-12. 被引量：1
6Houston S,Hougland P,Anderson JJ. Effectiveness of 0.12％ chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery[J].American Journal of Critical Care,2002.567-570. 被引量：1
7Grap MJ,Munro CL,Elswick RK Jr. Duration of action of a single,early oral application of chlorhexidine on oral microbial flora in mechanically ventilated patients:A pilot study[J].Heart and Lung,2004.83-91. 被引量：1
8Koeman M,van der Ven AJ,Hak E. Oral decontamination with chlorhexidine reduces incidence of ventilator-associated pneumonia[J].American Journal of Respiratory and Critical Care Medicine,2006.1348-1355. 被引量：1
9D'Amico R,Pifferi S,Leonetti C. Effectiveness of antibiotic prophylaxis in critically ill adult patients:Systematic review of randomised controlled trials[J].British Medical Journal,1998.1275-1285. 被引量：1
10Fourrier F,Duvivier B,Boutigny H. Colonization of dental plaque:A source of nosocomial infections in intensive care unit patients[J].Critical Care Medicine,1998.301-308. 被引量：1

二级参考文献7

1American Thoracic Society,Infectious Diseases Society of A-merica Guidelines for the management of adults with hospital-acquired,ventilator-associated,and health-care-associatedpneumonia[J].Am J Respir Crit Care Med,2005,171(4):388-416. 被引量：1
2Artinian V,Krayem H,DiGiovine B.Effects of early enteralfeeding on the outcome of critically ill mechanically ventilatedmedical patients[J].Chest,2006,129(4):960-967. 被引量：1
3Brain Trauma Foundation;American Association of Neuro-logical Surgeons;Congress of Neurological Surgeons.Guide-lines for the management of severe traumatic brain injury[J].J Neurotrauma,2007,24:S1-S106. 被引量：1
4Bronchard R,Albaladejo P,Brezac G,et al.Early onsetpneumonia:risk factors and consequences in head traumapatients[J].Anesthesiology,2004,100(2):234-239. 被引量：1
5Josephson SA,Moheet AM,Gropper MA,et al.Ventilator-associated pneumonia in a neurologic intensive care unit doesnot lead to increased mortality[J].Neurocirit Care,2010,12(2):155-158. 被引量：1
6聂英,黄秀良.重症颅脑创伤患者气管切开下呼吸道感染监测分析及对策[J].中华医院感染学杂志,2009,19(9):1058-1059. 被引量：33
7董明驹,史莉,杨富强,孙光成.呼吸机相关性肺炎病原菌的耐药性调查[J].中华医院感染学杂志,2011,21(1):158-159. 被引量：10