摘要
目的评价帕瑞昔布钠超前镇痛用于无痛胃镜中的临床效果和安全性。方法选择200例行无痛胃镜检查的患者,性别不限,年龄18～60岁,体重指数<30 kg/m2,ASAⅠ～Ⅱ级,随机分为对照组(生理盐水组)和实验组(帕瑞昔布组),每组100例。采用双盲法给药,麻醉诱导前20 min分别经静脉注射生理盐水2mL或帕瑞昔布钠40 mg。之后静脉推注丙泊酚1 mL/6 s,待患者睫毛反射消失后停止注射并行胃镜检查术,术中根据患者情况追加少量丙泊酚。记录HR、MAP、SpO2变化及麻醉诱导时间、胃镜检查时间、丙泊酚用量、术后苏醒时间;记录术中体动反应、呼吸暂停、低氧血症、心动过缓、低血压、注射痛及术后有关并发症的发生情况。结果两组患者麻醉诱导时间、术后苏醒时间和内镜检查时间比较差异无统计学意义(P>0.05),与对照组相比,实验组的丙泊酚用量减少(P<0.05),且术中体动反应、低氧血症、心动过缓、低血压、注射痛和呼吸暂停的发生率明显降低(P<0.05)。结论帕瑞昔布钠用于无痛胃镜检查麻醉具有良好的效果,并能降低不良反应发生率。
Objective To evaluate the effects of parecoxib on preemptive analgesia in patients undergoing painless gastroscopy. Methods In a double-blind study, 200 ASA Ⅰ - Ⅱ patients of both sexes aged 20 - 60 years with body mass index 〈 30 kg/m^2 were randomized into parecoxib group and control group, 100 patients in each group. In parecoxib group, parecoxib 40 mg in 2 mL of normal saline（ NS ） was injected intravenously for 20 min before induc-tion of anesthesia. In control group, NS 2 mL was injected instead of parecoxib. Propofol was injected intravenously at 1 mL/6 s until disappearance of eyelash reflect. Gastroscopy was performed. Additional propofol was given according to the patients response to surgical stimuli. HR, MAP, SpO2 , anesthesia induction time, gastroscopy time, the amount of propofol administered and recovery time were recorded. In addition, intraoperative body movement, apnea, hypoxemia, bradycardia,hypotension, injection pain and postoperative complications were also recorded. Results There was no significant difference in anesthesia induction time, recovery time and gastroscopy time between the two groups （P 〉 0. 05 ）. Compared with control group, the amount of propofol administered was fewer（ P 〈 0. 05 ）, and the incidences of intraoperative body movement, apnea, hypoxemia, bradycardia, hypotension, injection pain were lower （ P 〈 0. 05 ）. Con-clusion Intravenous oarecoxib has good effect with low rate of drug reaction.
出处
《实用药物与临床》
CAS
2013年第1期26-28,共3页
Practical Pharmacy and Clinical Remedies
