摘要
目的探讨婴幼儿时期接受全身麻醉与手术是否影响儿童远期的智力和感觉统合能力的发育。方法选取0。3岁在全身麻醉下接受非神经外科、非心胸外科手术的患儿100例作为麻醉组，根据麻醉次数分为一次麻醉50例和多次麻醉50例。根据麻醉组患儿的性别、年龄、教育背景等影响智力发育的主要因素作为匹配条件，选择50例0～3岁未经历过全身麻醉与手术的健康儿童作为对照组。分别采用韦氏儿童智力量表第4版中文版、学龄儿童感觉统合评定量表评估两组患儿的智力和感觉统合能力。结果在智力发育方面，两组患儿总智商、言语理解指数、知觉推理指数、工作记忆指数、加工速度指数、一般能力指数、认知效率指数比较差异均无统计学意义（P〉0．05）。在智力结构方面，麻醉组一次麻醉与多次麻醉患儿言语理解指数。工作记忆指数具有临床差异的阳性率高于对照组[12．O％（6／50）和26．0％（13／50）比6．O％（3／50），P〈0．05]。两组总体感觉统合能力失调的发生情况比较差异无统计学意义（P〉0．05），但麻醉组多次麻醉患儿前庭功能失衡的发病率高于一次麻醉E44．0％（22／50）比22．0％（11／50），P〈0．05]。结论总体上婴幼儿时期全身麻醉、手术经历对儿童远期的智力和感觉统合能力发育无明显影响，但麻醉患儿在智力结构方面言语理解指数。工作记忆指数出现临床差异的发生率增高，婴幼儿时期接受多次麻醉与手术者前庭功能失衡发生率增高。
Objective To investigate the long-term effects of early exposure to general anesthesia and surgery on children＇s intelligence and sensory integration function. Methods One hundred children who received general anesthesia and non-neurosurgery and non-cardiac-chest surgery operation （anesthesia group） ,were divided into one time anesthesia and multiple anesthesia. Fifty healthy children who did not receive general anesthesia and operation were as control group. There was no significant difference between 2 groups in sex,age,educational background etc. The Wechsler intelligence scale for children-fourth edition （Chinese version） and the child sensory integration check list were used to evaluate the intelligence and sensory integration function of the 2 groups. Results In development of intelligence, there was no significant difference between 2 groups in full intelligence quotient, verbal comprehension index, perceptual reasoning index, working memory index, processing speed index, general ability index and cognitive productive index. In intelligence structure, the incidence of clinically meaningful difference between verbal comprehension index-working memory index was significantly higher in anesthesia group one time and multiple anesthesia than that in control group [I2.0%（6/50） and 26.0%（13/50） vs. 6.0%（3/50）,P 〈0.05]. There was no significant difference in the incidence of sensory integration dysfunction between 2 groups. However,in anesthesia group, the incidence of vestibule balance dysfunction in multiple anesthesia was significantly higher than that in one time anesthesia [44.0%（22/50） vs. 22.0%（11/50）,P 〈0.05]. Conclusions In general, general anesthesia and surgery during the first three years of life has no significant long-term effects on children＇s intelligence and sensory integration function. However,the incidence of clinically meaningful difference between verbal comprehension index-working memory index increases in the anesthesia children. Children who received mul
出处
《中国医师进修杂志》
2013年第3期1-4,共4页
Chinese Journal of Postgraduates of Medicine
关键词
麻醉
智力
儿童
Anesthesia
Intelligence
Child
