摘要
目的:了解药品不良反应(ADR)发生一般规律及特征,为ADR监测和临床合理用药提供参考。方法:收集216例ADR报告,按年龄分布、给药途径、药品类型、ADR状态、涉及器官或系统及临床表现等进行统计、分析。结果:ADR可发生于各年龄段,以静脉注射给药引发的居首;216例ADR中涉及抗菌药物和中成药居前2位,其中头孢菌素类、喹诺酮类药物和中药注射剂发生频次较高;ADR临床表现以皮肤及其附件损害最为常见。结论:应加大临床ADR监测和报告力度,做好ADR知识宣传,合理用药,减少或避免ADR的发生。
Objective：To investigate the characteristics and disciplinarian of adverse drug reactions（ADR） in our hospital,in order to promote ADR monitoring and find phamarcovigilance signals.Methods：216 ADR cases were collected from Jan.2009 to Dec.2011,analyzed statistically and evaluated based on age,the route of administration,drug,ADR status,involved organ or tissue and clinical manifestations from the ADR reports in our hospital.Results：ADR can occur in all different ages,Injection was the main way for administration.The antibiotics and traditional Chinese medicine caused the higher proportion of ADR.Among them,the cephalosporins,the quinolones and the traditional Chinese medicine injection caused ADR were more than others.ADR harmed to skin or it＇s appendages were common.Conclusion：Great importance should be attached to the ADR monitoring,report,propaganda,and improve rational drug use to guard against ADR.
