摘要
目的分析急诊室救治措施与重型颅脑损伤患者预后之间的关系,为规范急诊室救治措施提供依据。方法回顾性分析重型颅脑损伤患者的出院病历,统计急诊室救治措施,包括气管插管、给氧、体液复苏、使用甘露醇等。患者到达神经外科ICU时的收缩压及脉搏血氧饱和度。预后指标包括住ICU时间和ICU死亡情况,出院时及伤后第6个月的Glasgow预后量表(GOS)分级。结果共140例重型颅脑损伤患者,65例(46.4%)在ICU治疗期间死亡,其中行气管插管者病死率为65.0%(39/60),未行气管插管者为32.5%(26180),差异有统计学意义(P〈0.01);是否体液复苏和使用甘露醇者病死率分别为44.7%(46/403)、51.4%(19/37)和49.2%(31163)、44.2%(34/77),差异均无统计学意义(P〉0.05)。在住ICU时间方面,上述三种救治措施实施与否差异均无统计学意义(P〉0.05)。在出院时和伤后第6个月GOS分级方面,行气管插管者GOS分级4、5级所占比例分别为8.3%(5/60)和25.O%(15160),而未行气管插管者分别为27.5%(22180)和52.5%(42/80),差异有统计学意义(P〈0.01),而在体液复苏和使用甘露醇方面差异均无统计学意义(P〉0.05)。结论重型颅脑损伤患者在急诊室救治过程中应该慎重选择气管插管,可以不给予体液复苏和甘露醇。
Objective To assess the influence between managements in emergency room(ER) and outcome of severe traumatic brain injury (TBI),in order to provide inference for treatment. Methods A retrospective analysis was performed in severe TBI patients and recorded next indexes. ( 1 ) The managements in ER, including endotracheal intubation and oxygenation, fluid resuscitation, and mannitol intake. (2) The vital signs arriving at ICU, including systolic pressure and blood oxygen saturation. (3) Prognostic indicators including inhospital mortality and days during ICU, the scores of Glasgow outcome scale (GOS) at discharge and 6 months after injury. Results In 140 severe TBI patients, 65 patients (46.4%) died during ICU. The mortality of patients with endotracheal intubation [ 65.0% (39/60)] was significantly higher than that without endotracheal intubation [ 32.5%(26/80)] (P 〈 0.01 ). The mortality in whether fluid resuscitation and using mannitol had no significant difference [ 44.7% (46/103) vs. 51.4% (19/37), 49.2% (31/63) vs. 44.2% (34/77) ] (P 〉 0.05). In days during ICU, there was no significant difference among the three treatment measures (P〉 0.05). In GOS grade at discharge and 6 months after injury, the proportion of 4 and 5 grade were 8.3% (5/60) and 25.0% (15/60) in patients with endotraeheal intubation, while 27.5% (22/80) and 52.5% (42/80) in patients without endotracheal intubation (P 〈 0.01 ). In fluid resuscitation and using mannitol patients, there were no significant difference(P 〉 0.05 ). Conclusion Treating severe TBI patients in ER, endotracheal intubation should be carefully chosen, fluid resuscitation and mannitol may not be given.
出处
《中国医师进修杂志》
2013年第2期6-8,共3页
Chinese Journal of Postgraduates of Medicine
基金
江苏省镇江市卫生科技重点项目(SH2011054)
江苏大学临床医学科技发展基金(JLY2010142)
关键词
颅脑损伤
急诊室
医院
预后
Craniocerebral trauma
Emergency service,hospital
Prognosis