摘要
目的了解缺血性脑卒中急性期患者血压昼夜变化的节律，分析血压昼夜变化节律与靶器官损伤以及预后之间的相关性。方法选择镇江市第一人民医院神经内科收治的缺血性脑卒中急性期患者共194例，根据血压类型将其分为四组：勺型、非勺型、超勺型、反勺型。常规生化检测并比较各组患者血糖、总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白以及超敏C反应蛋白，应用美国国立卫生研究院卒中量表（ymss）评分、Barthel评分检测患者神经功能情况。结果191例患者完成随访，其中勺型组75例，非勺型组66例，反勺型组34例及超勺型组16例。4组患者间三酰甘油、低密度脂蛋白以及超敏C反应蛋白水平总体比较差异有统计学意义（P〈0．05），其中超勺型、反勺型三酰甘油、超敏C反应蛋白水平与勺型、非勺型比较差异有统计学意义（P〈0．05），超勺型、反勺型低密度脂蛋白水平与勺型比较差异有统计学意义（P〈0．05）。入院时NIHSS、Barthel评分情况对比显示，勺型组NIHSS、Barthel评分与非勺型、超勺型及反勺型组比较差异有统计学意义（P〈0．05）；3个月后勺型组NIHSS、Barthel评分与非勺型、超勺型及反勺型组比较差异有统计学意义（P〈0．05）；3个月后勺型、非勺型、超勺型及反勺型组的N1HSS、Barthel评分与人院时比较差异均有统计学意义（P〈0．05）。结论血压昼夜节律的消失是缺血性脑卒中急性期患者的特点之一，发病后3个月的预后相对也较差。
Objective To explore the blood pressure variation ofischemic stroke patients, and analyze the correlation of blood pressure variation with target organ damage and prognosis of these patients. Methods One hundred and ninety-four patients with acute phase ischemic stroke, admitted to our hospital from January 2008 to April 2012 were selected in our hospital; these patients were divided into four groups according to the blood pressure styles： the extreme dippers, reverse dippers, non-dippers and dippers. The levels of glucose, total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein （HDL）, low-density lipoprotein （LDL） and high-sensitivity C reactive protein （Hs-CRP） were detected; and the neurological function of the patients was scored by National Institutes of Health Stroke Scale （NIHSS） and Barthel scale. Results Follow-up was finished in 191 patients, including 75 cases of dippers groups, 66 cases of non-dippers groups, 33 cases of reverse dippers groups and 16 cases of extreme dippers groups. The levels ofTG, LDL and Hs-CRP showed statistically significant differences among the four groups （P〈0.05）; the levels of TG and Hs-CRP in the reverse dippers group and extreme dippers group had statistically differences as compared with those in the non-dippers group and dippers group （P〈0.05）; the level of LDL in the reverse dippers group and extreme dippers group showed statistical differences as compared with that in the dippers group （P〈0.05）. The dippers group had statistical differences of NIHSS and Barthel scale scores at admission as compared with the reverse dippers group, non-dippers group and extreme dippers group （P〈0.05）; NIHSS and Barthel scale scores inthe four groups showed significant differences between three months after treatment and at admission （P〈0.05）. Conclusion The blood pressure variation is one of the characteristics of acute phase ischemic stroke patients; the prognosis is poor three months after the onset.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2013年第2期157-160,共4页
Chinese Journal of Neuromedicine
关键词
缺血性脑卒中
高血压
预后
Ischemic stroke
Hypertension
Prognosis
