摘要
宫颈癌发病率呈上升和年轻化趋势,宫颈癌的发生发展是一个漫长的过程,阻断这一过程是预防宫颈癌前病变及宫颈癌的主要途径。目前,液基细胞学(liquid-based cytology,LBC)技术是筛查宫颈病变最优质的检测方法,在宫颈细胞样本采集、制片以及阅片过程中采用了更先进的技术,克服以往巴氏涂片技术的不足,LBC技术的发展主要分为三个阶段,即新柏氏膜式薄层细胞学(ThinPrep Cytologic Test,TCT)、液基离心沉淀式薄层细胞学(AutoCyte Prep)和新柏氏影像系统(ThinPrep Imaging System,TIS)。液基细胞筛查技术应用于临床已明显降低宫颈癌的发病率和死亡率,但受到客观技术设施的影响,液基细胞筛查技术仍存在一些不足,如何弥补这一缺憾,人乳头瘤病毒(human papilloma virus,HPV)-脱氧核糖核酸(deoxyribonucleic acid,DNA)检测联合LBC检查作为宫颈病变筛查模式将成为未来的主流趋势。
The incidence rate of cervical cancer was increasing worldwide, with steady upward trends in young women. Fortunately, the development of cervical cancer experienced a long process, which provided a great chance to catch the cervical cancer before it progressed. At present, Liquid - based cytology （LBC） technology was one of the best screening methods which overcame technical deficiencies of Papanicolaou smears and utilizes more advanced technology in course of sampling, processing and reading, cervical cells. Development of Liquid - based cytology technology was mainly divided into three stages, including ThinPrep Cytologic Test （TCT）, AutoCyte Prep and ThinPrep Imaging System （TIS）. Clinical application of liquid - based cytological screening technology has significantly reduced cervical cancer incidence and mortality. However, owing to the objective technical causes, Liquid- based cytological screening technology still had some deficiencies. To compensate for the defects, human papilloma virus （HPV） -deoxyribonucleic acid（DNA） test combining with LBC screening technology would become the future trend of cervical lesion screening model.
出处
《中国计划生育和妇产科》
2013年第1期20-23,共4页
Chinese Journal of Family Planning & Gynecotokology
基金
国家自然基金项目(编号:81272877)
关键词
液基细胞学
宫颈病变
筛查技术
liquid - based cytology
cervical lesion
screening technology
