摘要
目的:探讨固本化瘀方干预溃疡性结肠炎(UC)复发的疗效以及对血清肿瘤坏死因子(TNF-α)水平的影响。方法:将84例UC患者随机分为治疗组44例和对照组40例,治疗组给予固本化瘀方加柳氮磺胺毗啶口服方案治疗;对照组仅给予柳氮磺胺毗啶口服,并以20例健康志愿者作为正常对照组。治疗3个月后观察两组近期临床总体疗效,随访6个月后观察两组复发情况,并检测两组治疗前后以及健康对照组血清TNF-α水平。结果:治疗组近期临床总体疗效优于治疗组(P<0.05);治疗组复发率明显低于对照组(P<0.05);治疗组治疗后患者血清TNF-α水平明显高于对照组及健康对照组(P<0.05),复发患者血清TNF-α水平高于未复发患者,组间存在极显著差异(P<0.01),治疗后、随访时,治疗组血清TNF-α水平皆显著低于对照组(P<0.05);但随访时在两组间比较,无显著差异。结论:健脾化瘀法治疗溃疡性结肠疗效显著,并可降低复发率,其抗复发作用机制可能是与抑制外周血炎性因子TNF-α的过度表达相关。
Objective ： To observe the therapeutic effect of Guben Huayufang for the relapse of ulcerative colitis （UC） and its influence on serum tumor necrosis factor-α （TNF-α）. Method： Eighty-four patients with UC were divided into two groups randomly, 44 cases in treatment group treated with the Guben Huayufang plus salazosulfapyridine and 40 cases in control group treated with salazosulfapyridine. And a normal control group with 20 healthy volunteers was set. After three months, the general therapeutic effect of the two groups and the relapse information were observed after 6 months, also the serur＇n TNF-α were detect before and after the therapy in three groups. Result： The therapeutic effect of treatment group is better than control group （P 〈 0.05） ; the relapse ratio of treatment group is lower than control group （P 〈 0.05）. After the treatment, the serum TNF-α in treatment group is higher than control group and healthy control group （P 〈 0.05）. And the serum TNF-α in the relapse patients is higher than patients who has not relapsed （P 〈 0.01 ）. After the treatment, and during the follow-up, the serum TNF-α in treatment group is lower than control group （P 〈 0.05） ; but with no difference during the follow-up. Conclusion： The therapeutic effect of Guben Huayufang for UC is significant, and can lower the relapse ratio. The mechanism might be that it can lower the expression of serum TNF-α.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第3期272-275,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广东省科技厅项目(201110606)
