摘要
核因子-κB（NF-κB）是一种重要的核转录因子，广泛参与炎症介质、黏附分子、趋化因子和一些炎性相关酶类的基因调控，引起免疫损伤。血管细胞黏附分子-1（vascular cell adhesion molecule-1，VCAM-1）属于免疫球蛋白超家族成员，能介导炎症细胞与血管内皮细胞的黏附引起炎症损伤。VCAM-1基因的启动子区域包含许多功能串联的NF-κB站点，NF-κB激活可使VCAM-1持续表达引起免疫炎症损伤。目前研究发现免疫炎症是各种肾脏疾病的发病基础，该文就NF—κB、VCAM-1在肾脏疾病中的作用及其研究进展进行综述。
Nuclear factor kappa B （ NF-κB ） is an important nuclear transcription factor involved in a wide range of inflammatory mediators, adhesion molecules, chemokines and inflammatory-related enzymes in gene regulation,causing immune damage. Vascular cell adhesion molecule-1 （VCAM-1）, an adhesion molecule, belongs to the immunoglobulin superfamily and can mediate adhesion of inflammatory cells and endothelial cells caused by inflammatory injury. VCAM-1 gene promoter region contains a series of many of the features of NF-κB site. NF-κB activation can increase the expression of VCAM-1 that causes the immune and inflammatory in-jury. Present study has found that immune inflammation is the basis of a variety of renal diseases. NF-κB, VCAM-1 in kidney disease and its research progress may be discussed in this article.
出处
《国际儿科学杂志》
2013年第1期41-44,共4页
International Journal of Pediatrics
