摘要
目的观察糖尿病黄斑水肿（DME）患者中心凹下脉络膜厚度（SFCT）的变化。方法横断面观察研究。20例DME患者32只眼纳入研究。男性12例，女性8例。平均年龄（57．6土9．3）岁。均行最佳矫正视力（BCVA）、频域（SD）光相干断层扫描（OCT）、验光检查。根据OCT黄斑水肿形态，分为弥漫水肿型、囊样水肿型、浆液性神经上皮脱离型、硬性渗出为主型。应用CirrusHD-OCT对患眼黄斑区行加强深度扫描（EDI），测量SFCT。与国内同年龄段正常人群平均SFCT值（286．84±28．80）μm进行比较。患者年龄、屈光度、糖尿病病程、空腹血糖、BCVA、中央视网膜厚度与SFCT的相关性应用Pearson相关分析；不同类型黄斑水肿问SFCT差异比较行单因素变量分析。结果患眼SFCT120．50～361．50μm，平均SFCT（223．81±43．74）μm，与正常人群平均SFCT值比较，厚度下降63．03μm，差异有统计学意义（95％可信区间一78．80～一47．26μm，P％0．01）；相关性分析结果显示，SFCT与患者年龄（r=0．124）、屈光度（r=0．277）、糖尿病病程（r＝0．286）、空腹血糖水平（r＝0．408）、BCVA（r＝0．087）、中央视网膜厚度（r＝0．036）无相关性（P〉O．05）；不同类型黄斑水肿之间SFCT值比较，差异无统计学意义（F＝0．042，P〉0．05）。结论DME患者SFCT较同年龄段正常人群明显变薄。
Objective To observe the subfoveal choroidal thickness （SFCT） in eyes of patients with diabetic macular edema （DME）. Methods Twenty patients （32 eyes） with DME were enrolled in this cross- sectional observational study. The patients included 12 males and eight females, with a mean age of （47.3±10.2） years. All the patients were examined documenting best corrected visual acuity （BCVA）, spectral domain optical coherence tomography （OCT） and ophthalmological examination. According to OCT DME morphology, samples are divided into diffuse macular edema, cystoid macular edema, serous retinal detachmenl and hard exudate groups. The SFCT was measured by a Cirrus HI＇OCT with enhanced depth imaging （EDI） and was compared with the average SFCT （286.84 ± 28.80） μm of same age group. Correlation between SFCT and age, diopter, diabetic duration, fasting blood glucose, BCVA and central retinal thickness were analyzed by Pearson Analysis. SFCT of different DME types were analyzed by ANOVA Analysis. Results The mean SFCT of 32 eyes was （223.81±43.74） μm （ranging from 120.50 to 361.50 μm）, which was lower by 63.03 μm （95% confidence interval, 78.80 to --47.26μm, P〈0.01） from normal SFCT. SFCT was independent of age （r=0. 124）, diopter （r=0. 277）, diabetic duration （r= 0. 286）, fasting blood glucose （r=0. 408）, BCVA （r= 0. 087）, and central retinal thickness （r=0. 036）. There was no significant difference of SFCT between different DME types （F = 0. 042, P 〉 0.05）. Conclusion SFCT is thinner in eyes with DME as compared to normal eyes of the same age.
出处
《中华眼底病杂志》
CAS
CSCD
北大核心
2013年第1期9-12,共4页
Chinese Journal of Ocular Fundus Diseases
基金
国家重点基础研究发展计划（973计划）（2011CB707506）
上海市医学引导项目（124119a9600）
